Publications by authors named "Leopoldo Henrique Barboza Martins"
Soluble epoxide hydrolase inhibitor blockage microglial cell activation in subnucleus caudalis in a persistent model of arthritis.
Rosanna Tarkany Basting Marcelo Henrique Napimoga Carlos Antônio Trindade Silva Henrique Ballassini Abdalla Braz Campos Durso Leopoldo Henrique Barboza Martins
Int Immunopharmacol
July 2023
Article Synopsis
- Rheumatoid arthritis (RA) leads to painful joint inflammation and can also affect the temporomandibular joint (TMJ), necessitating new treatment targets with fewer side effects.
- The use of epoxy-eicosatrienoic acids (EETs) shows promise for reducing inflammation, but their effectiveness is limited by the enzyme soluble epoxide hydrolase (sEH), making sEH inhibitors like TPPU a focus for enhancing EET action.
- In studies, TPPU treatment showed significant protective effects in arthritic models, improving TMJ morphology, reducing pain and inflammation, and modulating microglial and astrocyte activation in the nervous system.