Publications by authors named "Leonore Zagdoun"
Int J Mol Sci
November 2024
Article Synopsis
- Diminished ovarian reserve (DOR) and primary ovarian insufficiency (POI) significantly contribute to female infertility, with a recent study finding a genetic cause in 29.3% of POI cases.
- A prospective study of 120 patients with unexplained DOR revealed a 24.2% diagnostic yield using advanced sequencing technology to identify genes related to various biological pathways.
- Findings indicated that impaired oocyte quality is linked to meiosis/DNA repair genes, and the study supports the need for genetic testing as a routine part of infertility diagnosis and a potential predictor for progression to POI.
Article Synopsis
- Early gestational diabetes mellitus (eGDM) is diagnosed before 24 weeks of pregnancy, while standard GDM is diagnosed between 24 and 28 weeks using an oral glucose tolerance test; eGDM is associated with worse obstetric outcomes.
- A study compared postpartum glucose metabolism disorders in 500 women with eGDM (Group 1) and standard GDM (Group 2), revealing that eGDM patients required more insulin during pregnancy but had fewer preterm labors and fetal complications.
- Despite differences in treatment and outcomes during pregnancy, the rates of postpartum glucose metabolism disorders were similar between the two groups, indicating a high frequency of these disorders in both categories.
