Publications by authors named "Leonor Santana"
Article Synopsis
- A 32-year-old woman with a history of anorexia nervosa experienced worsening bingeing and purging behaviors, leading to an evaluation that revealed a body mass index near the underweight range and indicative symptoms of bulimia nervosa (BN).
- Despite no other psychiatric conditions like mood or anxiety disorders, she struggled with focus, time management, and completing tasks, affecting her personal and professional life.
- Treatment with fluoxetine and cognitive behavioral therapy did not help, but starting lisdexamfetamine significantly reduced her bingeing and purging behaviors while improving her concentration, suggesting a potential link between ADHD and bulimia nervosa in high-functioning adult women.
Benchmarking tools for transcription factor prioritization.
Comput Struct Biotechnol J
December 2024
Spatiotemporal regulation of gene expression is controlled by transcription factor (TF) binding to regulatory elements, resulting in a plethora of cell types and cell states from the same genetic information. Due to the importance of regulatory elements, various sequencing methods have been developed to localise them in genomes, for example using ChIP-seq profiling of the histone mark H3K27ac that marks active regulatory regions. Moreover, multiple tools have been developed to predict TF binding to these regulatory elements based on DNA sequence.
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