The Mediating Role of Sexual Boredom in Women's Sexual Desire and Satisfaction.

Sexual boredom in women is associated with various levels and dimensions of sexual desire, as well as lower sexual and relationship satisfaction. However, the directionality of these relationships remains unclear. This study aimed to investigate whether sexual boredom mediates the relationship between partner and attractive-other sexual desire and sexual and relationship satisfaction in a sample of 1155 Portuguese women in long-term monogamous relationships.

Sexual Boredom Inventory (SBI): Development and Initial Validation.

This study presents the development and validation of the Sexual Boredom Inventory (SBI), a 6-item measure assessing sexual boredom as a temporary, context-dependent state. Initial items were drafted from data obtained through qualitative analysis, and the SBI was tested using exploratory factor analysis (EFA) and confirmatory factor analysis (CFA) with a sample of adults reporting on their sexual experiences in the past month. A single-factor model was found to be the best fit, with four items dropped during refinement.

What Women Want? The State of the Art regarding the Treatment of Young Women with Hypoactive Sexual Desire Disorder.

Background: Hypoactive sexual desire disorder (HSDD) in premenopausal women involves biological, psychological, and social aspects. In the European Society for Sexual Medicine meeting in Rotterdam in February 2023, several leading experts in the field discussed the multifaceted nature of this disorder and the state of the art regarding treatment at a round table. This review reflects the information discussed at this event and further discusses current controversies.

Sexual boredom and sexual desire in long-term relationships: a latent profile analysis.

Background: Research suggests a general link between sexual boredom and sexual desire, but its understanding is currently very limited.

Aim: To identify distinct (latent) groups of women and men in long-term relationships based on their reported levels of sexual boredom and sexual desire.

Methods: Latent profile analysis (LPA) was conducted in an online sample of 1223 Portuguese participants aged 18 and 66 years (mean ± SD, 32.

CusProSe: a customizable protein annotation software with an application to the prediction of fungal secondary metabolism genes.

We report here a new application, CustomProteinSearch (CusProSe), whose purpose is to help users to search for proteins of interest based on their domain composition. The application is customizable. It consists of two independent tools, IterHMMBuild and ProSeCDA.

Ehlers-Danlos Syndrome in Prosthodontics, Periodontology, and Implant Dentistry: A Systematic Review of the Literature.

Ehlers-Danlos Syndrome (EDS) is one of the most common congenital connective tissue disorders, affecting the synthesis and production of collagen cells. The medical implications for joints, muscles, soft tissue, and blood circulation have been documented in the literature. Many oral manifestations are displayed in EDS patients, including gingival recession, lack of attached gingiva, early severe periodontitis, and dental anomalies and dental caries.

Clinical Considerations of Ehlers-Danlos Syndrome for Implant Dentistry: Two Case Reports.

Ehlers-Danlos Syndrome (EDS) is a group of congenital connective tissue disorders that commonly affect joints, muscles, soft tissue, and blood circulation in the affected population. Many oral manifestations are displayed in EDS patients that can include gingival recession, lack of attached gingiva, early severe periodontal disease, and dental caries. However, the literature is limited and oftentimes contradictory regarding dental implants in EDS patients.

Repair of a Non-Retentive Crown Over a Press-Fit Implant Placed 30 Years Prior: A Case Report.

Dental implant treatment has been proven to be a successful therapy to rehabilitate single, partial, and fully edentulous sites. Evidence shows that the use of implant-supported restorations is predictable and can deliver long-term success. However, discontinuation of implant systems can be challenging for prosthesis maintenance.

Women's Sexual Health During the Pandemic of COVID-19: Declines in Sexual Function and Sexual Pleasure.

Purpose Of The Review: The World Health Association declared COVID-19 a pandemic more than 1 year ago. We conducted a systematic review of the literature on the topic of women's sexual health during the pandemic, with a focus on sexual function and sexual pleasure. Our aim is to describe current findings and to discuss implications for women's sexual health during this period.

A Cluster Analysis on Sexual Boredom Profiles in A Community Sample of Men and Women.

Research evidence of the attributes of sexual boredom is extremely limited. Understanding variability in the experience of sexual boredom may offer relevant insights for the field of human sexuality. This study aimed to explore the co-occurrence of sexual boredom and other sexuality-related dimensions.

Psychosocial and Behavioral Aspects of Women's Sexual Pleasure: A Scoping Review.

Objectives: To clarify the psychosocial and behavioral factors related to women's sexual pleasure.

Methods: A search was conducted on EBSCO and Web of Science databases using the key terms "female sexual pleasure" and "women sexual pleasure" and following PRISMA guidelines.

Results: 76 articles were identified, referring to sexual practices, individual factors, interpersonal factors, societal factors, and ways of enhancing sexual pleasure.

A Systematic Review on Sexual Boredom.

Background: Empirical data on sexual boredom are scarce and unsystematized, contrasting with the literature on general boredom.

Aim: The aim of this review of literature is to verify how sexual boredom is defined in previous research and which relationships were found with sexual functioning, relationship dynamics, or gender.

Methods: A systematic search was conducted in EBSCO, Scopus, Web of Science, and PubMed databases for papers published until August 2020.

Perceptions of sexual boredom in a community sample.

This study explored the definitions of sexual boredom in a large community sample of Portuguese individuals. A thematic analysis of written responses to the question "What is sexual boredom for you?" was conducted with 653 participants aged 18 to 75 ( = 33.14;  = 9.

Patterns of sexual behavior and psychological processes in asexual persons: a systematic review.

Asexuality is commonly regarded as lack of sexual attraction. Research in asexuality grew progressively in the past two decades. However, asexuals' patterns of sexual behavior and psychological processes were not yet systematized.

Misdosing of Non-Vitamin K Antagonist Oral Anticoagulants in Primary Care.

Purpose: Prescription patterns of non-vitamin K antagonist oral anticoagulants (NOACs) are unknown among primary care physicians, where most patients with nonvalvular atrial fibrillation (NVAF) are diagnosed and followed up. The goal of this study was to evaluate overdosing and underdosing of NOACs in patients with NVAF followed up in primary care and determine their clinical predictors.

Methods: This multicenter cross-sectional study included all patients with NVAF followed up in 13 primary care units in the center region of Portugal.

The Link Between Boredom and Hypersexuality: A Systematic Review.

Background: Some conceptualizations of hypersexuality posit boredom as a possible trigger of hypersexual behavior.

Aim: This work aims to review published articles addressing the link between boredom and hypersexuality to investigate if this relationship can yet be established based on current empirical data.

Methods: This systematic review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines.

The Revisited Genome of Bacillus subtilis Bacteriophage SPP1.

bacteriophage SPP1 is a lytic siphovirus first described 50 years ago [1]. Its complete DNA sequence was reported in 1997 [2]. Here we present an updated annotation of the 44,016 bp SPP1 genome and its correlation to different steps of the viral multiplication process.

Bacteriophage SPP1 pac Cleavage: A Precise Cut without Sequence Specificity Requirement.

In many tailed bacteriophages, DNA packaging is initiated by recognition and cleavage of a specific sequence pac by the small (TerS) and large (TerL) terminase subunits. It was previously shown that the SPP1 pac region has two sequences where TerS binds (pacR and pacL), flanking the segment where TerL cleaves the SPP1 DNA (pacC). However, the pac-specific sequences required to achieve this endonucleolytic cut were not established.

Headful DNA packaging: bacteriophage SPP1 as a model system.

Tailed bacteriophages and herpesviruses package DNA inside the viral capsid by a powerful molecular motor. This packaging machine is composed of the portal protein, which provides a gate for DNA entry, the large terminase subunit whose ATPase activity fuels DNA translocation, and most frequently, a small terminase subunit that recognizes the viral packaging site. Here we review the mechanisms how the virulent Bacillus subtilis phage SPP1 packages DNA into a preformed procapsid.

The nuclease domain of the SPP1 packaging motor coordinates DNA cleavage and encapsidation.

The large terminase subunit is a central component of the genome packaging motor from tailed bacteriophages and herpes viruses. This two-domain enzyme has an N-terminal ATPase activity that fuels DNA translocation during packaging and a C-terminal nuclease activity required for initiation and termination of the packaging cycle. Here, we report that bacteriophage SPP1 large terminase (gp2) is a metal-dependent nuclease whose stability and activity are strongly and preferentially enhanced by Mn(2+) ions.

Direct interaction of the bacteriophage SPP1 packaging ATPase with the portal protein.

DNA packaging in tailed bacteriophages and other viruses requires assembly of a complex molecular machine at a specific vertex of the procapsid. This machine is composed of the portal protein that provides a tunnel for DNA entry, an ATPase that fuels DNA translocation (large terminase subunit), and most frequently, a small terminase subunit. Here we characterized the interaction between the terminase ATPase subunit of bacteriophage SPP1 (gp2) and the procapsid portal vertex.

[Affective touch according the nurse's perspective].

This study aimed at investigating the conception of nurses about the affective touch as a tool for care promotion and to identify its meanings in nursing care and the moment when it is used as care instrument. Qualitative research differentiating two ways to touch: instrumental touch (objective care) and the affective touch (subjective care). For data collection a semi-structured interview was used, with three assistance nurses of two hospitals in the South Region of Brazil.

Structural rearrangements between portal protein subunits are essential for viral DNA translocation.

Transport of DNA into preformed procapsids is a general strategy for genome packing inside virus particles. In most viruses, this task is accomplished by a complex of the viral packaging ATPase with the portal protein assembled at a specialized vertex of the procapsid. Such molecular motor translocates DNA through the central tunnel of the portal protein.

Modulation of the viral ATPase activity by the portal protein correlates with DNA packaging efficiency.

DNA packaging in tailed bacteriophages and herpesviruses requires assembly of a complex molecular machine at a specific vertex of a preformed procapsid. As in all these viruses, the DNA translocation motor of bacteriophage SPP1 is composed of the portal protein (gp6) that provides a tunnel for DNA entry into the procapsid and of the viral ATPase (gp1-gp2 complex) that fuels DNA translocation. Here we studied the cross-talk between the components of the motor to control its ATP consumption and DNA encapsidation.

A defined in vitro system for DNA packaging by the bacteriophage SPP1: insights into the headful packaging mechanism.

Tailed icosahedral bacteriophages and other viruses package their double-stranded DNA inside a preformed procapsid. In a large number of phages packaging is initiated by recognition and cleavage by a viral packaging ATPase (terminase) of the specific pac sequence (pac cleavage), which generates the first DNA end to be encapsidated. A sequence-independent cleavage (headful cleavage) terminates packaging, generating a new starting point for another round of packaging.