Publications by authors named "Leonor Nogales-Martin"
Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of the ongoing coronavirus disease 2019 (COVID-19) pandemic. Understanding the physiological and immunological processes underlying the clinical manifestations of COVID-19 is vital for the identification and rational design of effective therapies.
Aim: To describe the interaction of SARS-CoV-2 with the immune system and the subsequent contribution of hyperinflammation and abnormal immune responses to disease progression together with a complete narrative review of the different immunoadjuvant treatments used so far in COVID-19 and their indication in severe and life-threatening subsets.
Beta Blockers as Salvage Treatment in Refractory Septic Shock Complicated With Dynamic Left Ventricular Outflow Tract Obstruction: A Rare Case Presentation.
J Investig Med High Impact Case Rep
December 2021
Hypotension is the main finding in patients admitted to an intensive care unit (ICU) with the diagnosis of septic shock and it is related to worse outcomes. In these patients, several underlying causes of hypotension may co-exist, including vasoplegia, hypovolemia, drug-mediated venodilation, or myocardial dysfunction. Nowadays, echocardiography has been positioned as an essential tool in any ICU set to assess fluid status, ventricular ejection fraction, or any other myocardial complications.
View Article and Find Full Text PDFCirculating levels of calprotectin, a signature of neutrophil activation in prediction of severe respiratory failure in COVID-19 patients: a multicenter, prospective study (CalCov study).
Inflamm Res
January 2022
Article Synopsis
- The study investigates the significance of calprotectin levels in predicting the severity of COVID-19, focusing on its role in immune response and inflammation.
- A total of 395 COVID-19 patients were enrolled, with findings showing that higher calprotectin levels correlated with an increased need for invasive mechanical ventilation and ICU admission.
- The results indicate that serum calprotectin is a valuable early predictor for determining the severity of COVID-19 in patients.
Coil prolapse or migration is a rare but potentially serious complication that may occur during aneurysm embolization, with no standard management currently described. Here we describe our experience with the Embolus Retriever with Interlinked Cages (ERIC) device® (Microvention, Aliso Viejo, CA, USA) for the retrieval of prolapsed or migrated coils in a case series and Flow-Model analysis. First, a retrospective review was performed using our institution database for patients in which coil prolapse or migration occurred during aneurysm embolization, and data was collected and analyzed.
View Article and Find Full Text PDFArticle Synopsis
- Early identification of patients at high risk for severe COVID-19 is critical, and this study focused on the relationship between mid-regional proadrenomedullin (MR-proADM), a biomarker of endothelial dysfunction, and patient outcomes.
- In a cohort of 99 COVID-19 patients, MR-proADM was found to be a strong predictor of 28-day mortality and progression to severe disease, outperforming other biomarkers in accuracy.
- The study concluded that elevated levels of MR-proADM are significantly associated with higher mortality and disease severity risk, suggesting it could be a valuable tool for early prognosis in COVID-19 cases.