Publications by authors named "Leonor B Marques"
Unlabelled: Infections caused by are a leading cause of mortality worldwide. infections caused by methicillin-resistant (MRSA) are particularly difficult to treat due to their resistance to next-generation β-lactams (NGBs) such as methicillin, nafcillin, and oxacillin. Resistance to NGBs, which is alternatively known as broad-spectrum β-lactam resistance, is classically mediated by PBP2a, a penicillin-binding protein encoded by (or ) in MRSA.
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- For years, scientists believed Gram-positive bacteria had no specialized machinery for elongation, but recent findings reveal they can elongate using a pair of proteins called SEDS and PBP during cell division.
- Researchers utilized the Nebraska Transposon Mutant Library to discover additional proteins, including GpsB, SsaA, and RodZ, that assist in the elongation process.
- GpsB specifically helps regulate the positioning of other penicillin-binding proteins (PBP2 and PBP4) at the cell division site, crucial for maintaining the correct shape and function of the bacteria, particularly important due to the rising threat of antibiotic-resistant infections.
Infections caused by are a leading cause of mortality worldwide. infections caused by Methicillin-Resistant (MRSA) are particularly difficult to treat due to their resistance to Next Generation β-lactams (NGB) such as Methicillin, Nafcillin, Oxacillin etc. Resistance to NGBs, which is alternatively known as broad-spectrum β-lactam resistance is classically mediated by PBP2a, a Penicillin-Binding Protein encoded by (or ) in MRSA.
View Article and Find Full Text PDFUnregulated cell cycle progression may have lethal consequences and therefore, bacteria have various mechanisms in place for the precise spatiotemporal control of cell cycle events. We have uncovered a new link between chromosome replication/segregation and splitting of the division septum. We show that the DNA translocase domain-containing divisome protein FtsK regulates cellular levels of a peptidoglycan hydrolase Sle1, which is involved in cell separation in the bacterial pathogen Staphylococcus aureus.
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