Retinoblastoma and p53 protein expression in pre-malignant oral lesions and oral squamous cell carcinoma.

The retinoblastoma (Rb) and p53 genes play a fundamental role in cell cycle mechanisms, and their deregulation is related to many steps of oral cancer carcinogenesis. This study was conducted to evaluate the expression of the p53 and Rb proteins in malignant and pre-malignant oral cavity lesions. This retrospective study was conducted at the Federal University of Bahia, Salvador, Brazil, and the Molecular Biology Laboratory of the Otorhinolaryngology Department at the University of Heidelberg, Heidelberg, Germany.

Histological and physical analysis of bone neoformation by osteogenesis distraction: A preliminary report.

Introduction: Osteogenesis distraction (OD) is a mainstream technique in maxillofacial surgical reconstruction with varied applications. OD technique employs a distractor with the aim to get new bone in the site of interest. Osseous maturation time is necessary before the device can be removed and few patients' complaint of related discomfort, especially when these devices are external, and induces superficial infections, paresthesia, hypertrophic scars and social relationship difficulties.

Histological evaluation of the effect of low-level laser on distraction osteogenesis in rabbit mandibles.

Objectives: This study evaluated the action of low level laser therapy (LLLT) on the percentage of newly formed bone in rabbit mandibles that underwent distraction osteogenesis (DO).

Study Design: Ten rabbits underwent bone lengthening according to the following protocol: Latency - 3 days; Activation - 7 days 0.7 mm/d; and Consolidation - 10 days.

Effects of low-level laser therapy on bone formed after distraction osteogenesis.

This study evaluated the effect of low-level laser therapy (LLLT) on the chemical composition, crystallinity and crystalline structure of bone at the site of distraction osteogenesis. Five rabbits were subjected to distraction osteogenesis (latency = 3 days; rate and frequency = 0.7 mm/day for 7 days; consolidation = 10 days), and three were given LLLT with arsenide-gallium-aluminum (AsGaAl; 830 nm, 40 mW): 10 J/cm(2) dose per spot, applied directly to the distraction osteogenesis site during the consolidation stage at 48 h intervals.

Is 3D-CT reformation using free software applicable to diagnosis of bone changes in mandibular condyles?

Objectives: This study evaluated the agreement of computed tomography (CT) imaging using 3D reformations (3DR) with shaded surface display (SSD) and maximum intensity projection (MIP) in the diagnosis of bone changes in mandibular condyles of patients with rheumatoid arthritis (RA), and compared findings with multiplanar reformation (MPR) images, used as the criterion standard.

Material And Methods: Axial CT images of 44 temporomandibular joints (TMJs) of 22 patients with RA were used. Images were recorded in DICOM format and assessed using free software (ImageJ).

Giant cell lesions with a Noonan-like phenotype: a case report.

Aim: The purpose of this article is to describe a case of multiple giant cell lesions of the mandible that occurred in a 14-year-old girl with phenotypic characteristics associated with Noonan Syndrome (NS).

Background: NS is a dysmorphic disorder characterized by hypertelorism, short stature, congenital heart defects, short and webbed neck, skeletal anomalies, and bleeding diathesis.

Report: A 14-year-old girl with a previous diagnosis of NS (sporadic case) presented with multiple radiolucent lesions in the body and ramus of her mandible.