Publications by authors named "Leonie Willebrands"
BMC Psychiatry
January 2021
Article Synopsis
- Antipsychotic-induced Weight Gain (AiWG) is a significant side effect of antipsychotic medications that can lead to serious health issues, including diabetes and decreased quality of life, but optimal treatment strategies are still unclear.
- This study is a randomized, double-blind trial that will compare the effects of metformin against a placebo in 256 overweight patients (BMI > 25) with schizophrenia who have been on antipsychotics for at least three months.
- The primary goal is to assess changes in body weight after 26 weeks of treatment, with secondary outcomes including the impact on metabolic syndrome, quality of life, and overall health, as well as evaluating cost-effectiveness and genetic factors related to BMI.
