Catheterized guinea pigs infected with Ebola Zaire virus allows safer sequential sampling to determine the pharmacokinetic profile of a phosphatidylserine-targeting monoclonal antibody.

Sequential sampling from animals challenged with highly pathogenic organisms, such as haemorrhagic fever viruses, is required for many pharmaceutical studies. Using the guinea pig model of Ebola virus infection, a catheterized system was used which had the benefits of allowing repeated sampling of the same cohort of animals, and also a reduction in the use of sharps at high biological containment. Levels of a PS-targeting antibody (Bavituximab) were measured in Ebola-infected animals and uninfected controls.

Denormalizing a historical problem: teen pregnancy, policy, and public health action.

Objective: To explore the impact of teen-adult sexual relationships as a public health threat and the effectiveness of statutory rape laws in protecting adolescent children.

Methods: A comprehensive review of current literature surrounding child abuse, teen pregnancy, and statutory rape was conducted.

Results: Of one million teen girls who become pregnant each year, two-thirds may be the victims of statutory rape.