Publications by authors named "Leonie Schumm"
Spreading depolarization (SD) describes a propagating neuronal mass depolarization within the cerebral cortex that represents a mediator of infarct development and strongly stimulates the metabolic rate of O2 consumption. Here, we investigated the influence of Spreading Depolarization (SD) on brain tissue partial pressure of O2 (ptiO2) within the peri-infarct tissue of patients suffering malignant hemispheric stroke (MHS). This prospective observational trial included 25 patients with MHS that underwent decompressive hemicraniectomy followed by subdural placement of electrodes for electrocorticography (ECoG) and neighboring implantation of a ptiO2 probe within the peri-infarcted cortex.
View Article and Find Full Text PDFSpreading depolarizations (SD) contribute to lesion progression after experimental focal cerebral ischemia while such correlation has never been shown in stroke patients. In this prospective, diagnostic study, we investigate the association of SDs and secondary infarct progression after malignant hemispheric stroke. SDs were continuously monitored for 3-9 days with electrocorticography after decompressive hemicraniectomy for malignant hemispheric stroke.
View Article and Find Full Text PDFEvidence is accumulating that the Coronavirus disease (COVID-19) can bring forth deficits in executive functioning via alterations in the dopaminergic system. Importantly, dopaminergic pathways have been shown to modulate how actions and perceptions are integrated within the brain. Such alterations in event file binding could thus underlie the cognitive deficits developing after a COVID-19 infection.
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- Severe COVID-19 is linked to issues like inflammation and low oxygen levels, with red blood cells (RBCs) being important in these processes, especially in children who may show mild symptoms.
- This study analyzed the deformability of RBCs in 121 students from Saxony, Germany, comparing those who tested positive for SARS-CoV-2 with those who did not.
- Results showed that RBC deformation was significantly higher in those who tested positive for up to 6 months post-infection, suggesting it could indicate a milder clinical course of COVID-19 in children and adolescents.
Purpose: To quantify the number of SARS-CoV-2 infections in students and teachers in 14 Secondary schools in eastern Saxony, Germany. Seroprevalence of SARS-CoV-2 antibodies in study population. Number of undetected cases.
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- Post-COVID19 issues like pediatric inflammatory multisystem syndrome (PIMS) and Long-COVID19 are becoming critical concerns, potentially affecting adolescents more than the virus itself.
- A survey involving 1,560 students from grades 8-12 assessed mental health symptoms and differences between seropositive (infected) and seronegative (not infected) adolescents.
- Findings showed similar reported symptoms in both groups, indicating that Long-COVID19 may not be as prevalent as once thought, highlighting the significant mental health effects during the pandemic.
Physiological effects of spreading depolarizations (SD) are only well studied in the first hours after experimental stroke. In patients with malignant hemispheric stroke (MHS), monitoring of SDs is restricted to the postoperative ICU stay, typically day 2-7 post-ictus. Therefore, we investigated the role of physiological variables (temperature, intracranial pressure, mean arterial pressure and cerebral perfusion pressure) in relationship to SD during the late phase after MHS in humans.
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