Publications by authors named "Leonie Schenk"
Article Synopsis
- Many drugs used in medicine come from bacterial natural products created by complex enzymes called nonribosomal peptide synthetases (NRPSs) that link amino acids together.
- This research identifies new recombination sites within a specific part of NRPSs, the thiolation (T) domain, paving the way for innovative engineering of these enzymes.
- The study introduces a method called "eXchange Unit between T domains" (XUT), which enables scientists to combine NRPS fragments with different characteristics to create specific drugs, such as a proteasome inhibitor constructed from five distinct NRPS pieces.
