Publications by authors named "Leonie M Windeln"
Article Synopsis
- SICLOPPS is a technique for creating libraries of cyclic peptides that can inhibit specific protein interactions, leading to the discovery of new drug candidates.
- The researchers improved the SICLOPPS screening process by incorporating next-generation sequencing and computational methods, which enhanced the hit rate for potential inhibitors.
- They successfully identified better inhibitors for the HIF-1α/HIF-1β protein interaction, and this new method can be applied to find inhibitors for various other protein targets.
Cytochromes P450 catalyze oxidation of chemically diverse compounds and thus offer great potential for biocatalysis. Due to the complexity of these enzymes, their dependency of nicotinamide cofactors and redox partner proteins, recombinant microbial whole cells appear most appropriate for effective P450-mediated biocatalysis. However, some drawbacks exist that require individual solutions also when P450 whole-cell catalysts are used.
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