What and how should we measure in paediatric oncology FDG-PET/CT? Comparison of commonly used SUV metrics for differentiation between paediatric tumours.

Background: In clinical routine, SUV and SUV are most often used to determine the glucose metabolism in tumours by F-FDG PET/CT. Both metrics can be further normalised to SUVs in reference regions resulting in a SUV ratio (SUV). The aim of the study was to directly compare several widely used SUVs/SUV with regard to differentiation between common tumours in paediatric patients; a special focus was put on characteristics of reference region SUVs.