Publications by authors named "Leonie D M Grandpierre"
Article Synopsis
- - The study aims to identify when brain atrophy rates accelerate in individuals with genetic frontotemporal dementia (FTD), focusing on presymptomatic stages to determine optimal treatment timing.
- - Researchers conducted magnetic resonance imaging on presymptomatic carriers of pathogenic variants over an average follow-up of 64 months, analyzing brain volumes against a large normative sample.
- - Findings revealed that pathogenic variant carriers exhibit accelerated brain volume decline, particularly in the frontal and temporal lobes, starting at age 45, suggesting that changes in brain structure precede noticeable symptoms of FTD.
