Exome-Wide Rare Variant Analyses in Sudden Infant Death Syndrome.

Objective: To determine whether a monogenic basis explains sudden infant death syndrome (SIDS) using an exome-wide focus.

Study Design: A cohort of 427 unrelated cases of SIDS (257 male; average age = 2.7 ± 1.

Cardiac Genetic Predisposition in Sudden Infant Death Syndrome.

Background: Sudden infant death syndrome (SIDS) is a leading cause of postneonatal mortality. Genetic heart diseases (GHDs) underlie some cases of SIDS.

Objectives: This study aimed to determine the spectrum and prevalence of GHD-associated mutations as a potential monogenic basis for SIDS.

Impact of clinical and genetic findings on the management of young patients with Brugada syndrome.

Background: Brugada syndrome (BrS) is an arrhythmogenic disease associated with sudden cardiac death (SCD) that seldom manifests or is recognized in childhood.

Objectives: The objectives of this study were to describe the clinical presentation of pediatric BrS to identify prognostic factors for risk stratification and to propose a data-based approach management.

Methods: We studied 106 patients younger than 19 years at diagnosis of BrS enrolled from 16 European hospitals.

Cardiac evaluation of pediatric relatives in sudden arrhythmic death syndrome: a 2-center experience.

Background: Sudden arrhythmic death syndrome defines a sudden unexpected and unexplained death despite comprehensive pathological and toxicological investigation. Previous studies have focused on evaluation of adult relatives. There is, however, a lack of data in children, leading to highly variable management.

Sudden unexplained death in infants and children: the role of undiagnosed inherited cardiac conditions.

Sudden unexplained death in childhood is a traumatic event for both the immediate family and medical professionals. This is termed sudden unexplained or arrhythmic death syndrome (SUDS/SADS) for children over 1 year of age while sudden unexplained death in infancy or sudden infant death syndrome (SUDI/SIDS) refers to unexplained deaths in the first year of life. There is increasing evidence for the role of undiagnosed inherited cardiac conditions, particularly channelopathies, as the cause of these deaths.