Publications by authors named "Leonidas Joao de Mello Junior"
Background: The use of RNA interference (iRNA) therapy has proved to be an interesting target therapy for the cancer treatment; however, siRNAs are unstable and quickly eliminated from the bloodstream. To face these barriers, the use of biocompatible and efficient nanocarriers emerges as an alternative to improve the success application of iRNA to the cancer, including breast cancer.
Results: A hybrid nanocarrier composed of calcium phosphate as the inorganic phase and a block copolymer containing polyanions as organic phase, named HNPs, was developed to deliver VEGF siRNA into metastatic breast cancer in mice.
Antitumor activity of methyl (Z)-2-(isothioureidomethyl)-2-pentenoate hydrobromide against leukemia cell lines via mitotic arrest and apoptotic pathways.
Biochim Biophys Acta Gen Subj
September 2019
In a previous study, we described a series of 28 aryl- and alkyl-substituted isothiouronium salts with antitumor activity and selectivity toward a leukemia cell line. Among the synthesized compounds, methyl (Z)-2-(isothioureidomethyl)-2-pentenoate hydrobromide (IS-MF08) showed conspicuous activity. In the present study, we investigated the mechanism of action of IS-MF08.
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- Humans may face risks from various nanoparticles found in consumer products, yet there's limited understanding of their combined toxicity in real-life scenarios.
- The study investigated the genotoxic effects of two specific nanoparticles: solid lipid nanoparticles (SLNs) and superparamagnetic iron oxide nanoparticles (SPIONs) when exposed together in mice.
- Results indicated that co-exposure to these nanoparticles led to significantly higher genetic damage and sperm abnormalities compared to exposure to each nanoparticles type alone, suggesting a potentially harmful interaction between them.