Publications by authors named "Leonid Vysochek"
Background: The β-adrenergic augmentation of cardiac contraction, by increasing the conductivity of L-type voltage-gated Ca1.2 channels, is of great physiological and pathophysiological importance. Stimulation of β-adrenergic receptors (βAR) activates protein kinase A (PKA) through separation of regulatory (PKAR) from catalytic (PKAC) subunits.
View Article and Find Full Text PDFAndersen-Tawil syndrome (ATS) type-1 is associated with loss-of-function mutations in gene. encodes the tetrameric inward-rectifier potassium channel Kir2.1, important to the resting phase of the cardiac action potential.
View Article and Find Full Text PDFArticle Synopsis
- Mutations in the Na1.5 gene, which encodes a cardiac sodium channel, are linked to serious heart rhythm issues and conduction diseases.
- A patient with severe heart rhythm problems was found to have two specific mutations in Na1.5 that affect its calcium-binding capabilities.
- Functional studies showed that one mutation made Na1.5 non-conductive, impacting its interaction with a regulatory subunit and calcium, highlighting the significance of specific regions of Na1.5 in its function and regulation.