Herpes simplex virus: treatment with antimicrobial peptides.

The herpes virus infection represents a significant challenge for public health. The innate immunity plays an important role in herpes simplex virus (HSV) elimination. The innate antiviral immunity has not been comprehensively studied.

Reactions of immune system to physical exercises.

The great attention to reactions of immune system to the physical exercises in sportsmen is linked to the growth of training volumes, to the increase of competition numbers and to the elevation of morbidity. Immune deficiency may be considered as the detonator of pathological processes among which acute respiratory diseases (ARD) are investigated most completely in sports medicine. Other pathologies require long-term observations, but it is not so simple to do due to the frequent renewal of sports groups.

Methodology of Immunology and Allergology Teaching.

In Russia the imminent experience is acquired dealing with teaching for clinical immunology with allergology in medical institutions. Since 1986 according to the directive of Ministry of Health "About the organization of chairs of immunology with allergology in 10 Medical Educational Institutions of Russian Federation" the teaching for immunology as a separate training discipline is carried out in many medical institutes of Russia. At present, teaching for immunology with allergology is given at the separate chairs and courses of more than 20 medical institutes of Russian Federation (Moscow, Smolensk, Kursk, Kazan, Novosibirsk, Tver, Ivanovo, Tomsk, Chelyabinsk, etc.

Current Features of Secondary (Acquired) Types of Immune Deficiency.

Secondary (acquired) types of immune deficiencies (SID) take a leading place in practice of modern clinical immunology. The causes for SID development are extremely variable. Special attention is concerned with accumulating facts about target action of microorganisms, and first of all viruses, on certain processes in immune system.

Apoptogenesis of Immunodeficiency Diseases.

The tremendous progress, which has been made in the study of cellular and molecular basis of the maturation and functioning of immune system allowed to reveal the fine pathogenetic mechanisms of many primary (genetically caused) immunodeficiencies in human. The programmed cellular death is well known to be the basic natural mechanism of positive and negative selection in T and B lymphocytes, directed to elimination of cells with defective antigen-cognitive receptors or with capacity to react against "self". The controlled apoptosis is considered to be an important mechanism for support of optimal balance in the immune system.

Complex of Natural Cytokines Regulate Post-Burn Regeneration in Cornea.

Cytokines form a kind of regulatory net which normal functioning is critical for development of inflammation and regeneration in eye, namely cornea. In connection with this, we studied effects of complex of natural cytokine obtained from pig and comprising activities of IL-1, IL-6, TNF, MIF, TGFbeta1, on post-burn regeneration in rabbit cornea. The cornea burn was induced by 10% NaOH and cytokine complex was locally administered (over month after the burn) to the regeneration site observed as wall-eye.

Effect of cytokines on the level of free radicals in the blood of patients with systemic and local staphylococcus infection.

An increased extracellular production of free radicals with bactericidal activity does not improve the efficacy of intracellular digestion of Staphylococci. The amount of intracellular oxygen reactive species generated by the neutrophils from patients with an infectious condition has been found considerably decreased as compared to healthy donors. On the other hand, the excess of secretion of free radicals into the extracellular space leads inevitably to the adaptive increase of antioxidant enzymes and, as a result, to an increase in the total antioxidant capacity of the blood plasma.

Pathogenetic Principle of Immune System Evaluation in Human: Positive and Negative Activation.

The main advantage of the pathogenetic principle for immune system evaluation is that the principle allows to optimize assessment of the main and accessory functions of immunocompetent cells. The investigation of immune system begins from the evaluation of cell recognition function, and then, step by step, the investigator moves further, while determining the capacity of immunocompetent cells to be activated, to proliferate and differentiate. The investigation of immune system may be terminated at its every stage once a defect in immune system is detected.