Publications by authors named "Leonid V Kharin"
Article Synopsis
- * Researchers found that when MSI2 is removed, it lowers the levels of another protein called EGFR, which is important for cancer cell growth.
- * Depleting MSI2 makes NSCLC cells, especially those with changes in EGFR, less able to grow and makes treatments that target EGFR more effective.
Colorectal cancer is the second most common cancer in women and third most common cancer in men. Cell signaling alterations in colon cancer, especially in aggressive metastatic tumors, require further investigations. The present study aims to compare the expression pattern of proteins associated with cell signaling in paired tumor and non-tumor samples of patients with colon cancer, as well as to define the cluster of proteins to differentiate patients with non-metastatic (Dukes' grade B) and metastatic (Dukes' grade C&D) colon cancer.
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