Publications by authors named "Leonid O Klimov"
Background: The development of essential hypertension is associated with a wide range of mechanisms. The brain stem neurons are essential for the homeostatic regulation of arterial pressure as they control baroreflex and sympathetic nerve activity. The ISIAH (Inherited Stress Induced Arterial Hypertension) rats reproduce the human stress-sensitive hypertensive disease with predominant activation of the neuroendocrine hypothalamic-pituitary-adrenal and sympathetic adrenal axes.
View Article and Find Full Text PDFBackground: The adrenals are known as an important link in pathogenesis of arterial hypertensive disease. The study was directed to the adrenal transcriptome analysis in ISIAH rats with stress-sensitive arterial hypertension and predominant involvement in pathogenesis of the hypothalamic-pituitary-adrenal and sympathoadrenal systems.
Results: The RNA-Seq approach was used to perform the comparative adrenal transcriptome profiling in hypertensive ISIAH and normotensive WAG rats.
Article Synopsis
- The study focuses on the hypothalamus' role in hypertension and stress, using rats with inherited stress-induced arterial hypertension (ISIAH) as a model.
- RNA sequencing identified 139 differentially expressed genes (DEGs) in ISIAH rats compared to normotensive rats, with 18 DEGs linked to arterial hypertension.
- Key biological processes and metabolic pathways associated with these DEGs include hormone regulation, immune response, and stress, highlighting potential therapeutic targets for managing stress-sensitive hypertension.
Background: The kidney mass is significantly increased in hypertensive ISIAH rats with Inherited Stress Induced Arterial Hypertension as compared with normotensive WAG rats. The QTL/microarray approach was carried out to determine the positional candidate genes in the QTL for absolute and relative kidney weight.
Results: Several known and predicted genes differentially expressed in ISIAH and WAG kidney were mapped to genetic loci associated with the absolute and relative kidney weight in 6-month old F2 hybrid (ISIAHxWAG) males.