Publications by authors named "Leonid A Shaposhnikov"
Lactobacilli and Klebsiella: Two Opposites in the Fight for Human Health.
Biochemistry (Mosc)
January 2024
The problem of antibiotic resistance is currently very acute. Numerous research and development of new antibacterial drugs are being carried out that could help cope with various infectious agents. One of the promising directions for the search for new antibacterial drugs is the search among the probiotic strains present in the human gastrointestinal tract.
View Article and Find Full Text PDFRibonucleoside hydrolases are enzymes that catalyze the cleavage of ribonucleosides to nitrogenous bases and ribose. These enzymes are found in many organisms: bacteria, archaea, protozoa, metazoans, yeasts, fungi and plants. Despite the simple reaction catalyzed by these enzymes, their physiological role in most organisms remains unclear.
View Article and Find Full Text PDFArticle Synopsis
- Oxidized nicotinamide adenine dinucleotide (NAD) is crucial for cellular metabolism and signaling, and this research develops a reliable enzymatic assay to measure NAD levels in human blood.
- The study compares NAD concentrations between healthy individuals and patients with cardiac or neurological diseases, finding significant reductions in NAD levels among these patient groups.
- The assay not only confirms expected NAD levels in healthy subjects but also highlights its potential as a diagnostic tool by offering better differentiation between cardiac and neurological patients through NAD ratio comparisons with other blood markers.