Muskelin Coordinates PrP Lysosome versus Exosome Targeting and Impacts Prion Disease Progression.

Cellular prion protein (PrP) modulates cell adhesion and signaling in the brain. Conversion to its infectious isoform causes neurodegeneration, including Creutzfeldt-Jakob disease in humans. PrP undergoes rapid plasma membrane turnover and extracellular release via exosomes.