Cinnamaldehyde modulates host immunoinflammatory responses in rat ligature-induced periodontitis and peripheral blood mononuclear cell models.

Cinnamaldehyde is a natural product with anti-inflammatory and immune-modulatory properties, known to regulate host responses to bacterial stimuli. This study aimed to investigate the effects of cinnamaldehyde on ligature-induced periodontitis in rats, and its impact on the modulation of human peripheral blood mononuclear cells (PBMC). Male Wistar rats were assigned into three groups:i) control: no ligature + vehicle; ii) ligature: ligature + vehicle; and iii) ligature + cinnamaldehyde (50 mg/kg); all treatments by daily oral gavage.

Trichomonas vaginalis as a risk factor for human papillomavirus: a study with women undergoing cervical cancer screening in a northeast region of Brazil.

Background: Human papillomavirus (HPV) and Trichomonas vaginalis (TV) infections are the most common sexually transmitted infections (STIs) globally. The latter has contributed to a variety of adverse outcomes for both sexes. Moreover, in Brazil, epidemiological studies on patients with STIs are limited.

Pool-based exercise for amelioration of pain in adults with fibromyalgia syndrome: A systematic review and meta-analysis.

Objective: To evaluate the effects of pool-based exercises on pain symptomatology among adults with fibromyalgia syndrome.

Methods: A systematic review and meta-analysis were carried out using PRISMA guidelines. Database search was conducted by two independent reviewers.

Urinary Incontinence in Climacteric Women With or Without Depressive Symptoms: A Cross-Sectional Study.

Objective: This study aimed to investigate whether the occurrence of urinary incontinence (UI) is associated with increased odds of depression in perimenopausal and postmenopausal women.

Methods: This cross-sectional study included 208 women with depressive symptoms, confirmed by the Beck Depression Inventory, and 247 patients without depression. All participants were perimenopausal or postmenopausal women aged 35 to 65 years who attended an outpatient clinic from a tertiary-academic hospital in Northeastern Brazil.

Protective effects of desipramine on alveolar bone in experimental periodontitis.

Background: Desipramine is a tricyclic antidepressant with immune-modulatory activity, whose effects on ligature-induced periodontitis are yet to be investigated. Hence, its actions on alveolar bone resorption, gingival collagen content and key inflammatory mediators were herewith analyzed.

Methods: A total of 60 male Wistar rats were randomly assigned into three groups: 1) control: rats without ligature treated with vehicle (saline); 2) ligature: rats with ligature-induced periodontitis treated with vehicle; 3) ligature + desipramine: rats with ligature-induced periodontitis treated with desipramine (20 mg/kg/d in vehicle).

Effects of Vitamin C on the Prevention of Ischemia-Reperfusion Brain Injury: Experimental Study in Rats.

Background: Reperfusion syndrome after carotid endarterectomy is a complication associated with cerebrovascular self-regulation in a chronically hypoperfused cerebral hemisphere, leading to severe neurological damage. Vitamin C is an important antioxidant in brain metabolism that has shown some neuroprotective actions.

Objective: To investigate the potential effects of vitamin C on cerebral reperfusion in comparison with placebo (saline) in rats.

Plasma Cytokine Levels in Overweight Versus Obese Disease-Free Perimenopausal Women.

Objective: To evaluate the plasma cytokine levels during T cell-mediated inflammatory responses and compare the metabolic markers between overweight and obese perimenopausal women without systemic diseases.

Methods: Sixty perimenopausal women were divided into two groups (overweight and obese). Participants in both groups had their waist-to-height ratio (WHtR) measured and blood samples collected for the evaluation of estradiol, fasting glucose, leptin, high-sensitivity C-reactive protein (hs-CRP), interleukin (IL)-6, IL-10, IL-17A levels, and lipid profile.

Randomized double-blind placebo-controlled trial of the effect of Morus nigra L. (black mulberry) leaf powder on symptoms and quality of life among climacteric women.

Objective: To test the efficacy of Morus nigra L. (MN) leaf powder for treating climacteric symptoms by comparison with hormone therapy (HT) and placebo.

Methods: A randomized controlled trial among 62 climacteric women attending Hospital of the Federal University of Maranhão, Brazil.

Hormonal, metabolic and inflammatory circulating biomarker profiles in obese and non-obese Brazilian middle-aged women.

Aim: To investigate circulating hormonal, metabolic and inflammatory biomarker profiles in obese and non-obese middle-aged women.

Methods: A total of 110 women, aged 40-60 years, were included in this cross-sectional study. Patients were allocated, according to the occurrence of menopause and body mass index (BMI), into four groups: PM0 (premenopausal non-obese), PM1 (premenopausal obese), M0 (postmenopausal non-obese), and M1 (postmenopausal obese).

Salivary biomarkers for caries susceptibility and mental stress in individuals with facial pain.

: To assess salivary biomarkers for dental caries susceptibility and mental stress in young adults with perceived facial pain.: Males and females who reported facial pain and pain-free controls participated in this study. Facial pain was investigated using the RDC/TMD.

Sex Differences in Salivary Parameters of Caries Susceptibility in Healthy Individuals.

Purpose: To investigate salivary parameters of caries susceptibility in men and women in order to identify potential variations due to sexual dimorphism.

Materials And Methods: A total of 46 female and 24 male patients, aged 18-40 years, participated in this study. Unstimulated saliva was collected for the evaluation of flow rate, pH, secretory IgA, Snyder test scores, and Streptococcus mutans counts (confirmed by PCR assay).

Screening and early detection of oral cancer: current controversies.

Some evidence suggests that the early detection of oral cancer (OC) during surveillance might improve survival rates. In addition to this, interventions aimed at enhancing public awareness and knowledge of signs, symptoms and risk factors of OC are thought to decrease the burden of disease. Nevertheless, there is much controversy with regard to the cost-effectiveness of population-based strategies for OC screening.

A closer look at strategies for preserving salivary gland function after radiotherapy in the head and neck region.

Radiation-induced damage to the salivary glands remains a major complication of using radiation therapy to treat head and neck cancer, and it has led a wide range of research attempting to resolve the problem. From this perspective, we sought to briefly discuss relevant and timely approaches aimed at protecting or regenerating irradiated salivary glands, thereby preventing the development of salivary hypofunction or rescuing the functional properties of damaged glands. Such findings include molecular, cell, tissue, organ, and drug-based therapies.

Oral microbiome, periodontitis and risk of head and neck cancer.

A wide range of studies has been successfully exploring the association between the human microenvironment, sustained inflammation, and cancer. Growing evidence has then emerged in this field over the past few years. Nevertheless, reliable data addressing the impact of the oral microbiome and periodontitis on the pathogenesis and risk of head and neck malignancies remain scarce.