Publications by authors named "Leonardo Talachia Rosa"
Article Synopsis
- Some DNA helicases are important for maintaining and adapting genomes by facilitating branch migration in homologous recombination pathways.
- RadA is a common bacterial helicase that aids in DNA repair and plays additional roles in natural transformation for some bacteria; while ComM serves a similar purpose in Gram-negative bacteria.
- The study presents cryoEM structures of RadA and ComM with DNA and ATP analogs, highlighting how ATP hydrolysis and DNA binding are interconnected, along with the function of a shared domain in these helicases.
Bacteria have evolved toxins to outcompete other bacteria or to hijack host cell pathways. One broad family of bacterial polymorphic toxins gathers multidomain proteins with a modular organization, comprising a C-terminal toxin domain fused to a N-terminal domain that adapts to the delivery apparatus. Polymorphic toxins include bacteriocins, contact-dependent growth inhibition systems, and specialized Hcp, VgrG, PAAR or Rhs Type VI secretion (T6SS) components.
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