Publications by authors named "Leonardo Spinoglio"
Int J Mol Sci
October 2024
Article Synopsis
- Proliferative vitreoretinopathy (PVR) causes fibrotic membranes that lead to recurrent retinal detachment, with current treatment (pars plana vitrectomy) having high recurrence rates due to unresolved underlying issues.
- There are no approved pharmacological therapies for PVR, largely because of ethical and safety concerns in preclinical and in vivo studies.
- The review discusses the potential of computational models and Digital Twins in developing personalized treatment strategies, highlighting nintedanib as a promising drug candidate for simulating effects on fibrotic pathways.
