Single-blind and Double-blind Randomized Controlled Trials of Palmtherapy(R), an Alternative Medical Approach, for Anxiety before Cardiac Catheterization.

Alternative medicine is widely used, but lacks consensus regarding its amenability to scientific investigation. Anxiety increases morbidity and mortality in ischemic heart disease. We performed two studies of Palmtherapy(R), an alternative treatment, for anxiety before cardiac catheterization.

Clinical and hemodynamic effects of bosentan dose optimization in symptomatic heart failure patients with severe systolic dysfunction, associated with secondary pulmonary hypertension--a multi-center randomized study.

Objective: To evaluate the effects of bosentan on echo-derived hemodynamic measurements, and clinical variables in symptomatic heart failure (HF) patients.

Method: Multi- center, double-blind, randomized (2:1), placebo-controlled study comparing bosentan (8-125 mg b.i.

"Benign" course and malignant clinical presentations of congenital long QT syndrome.

This report describes the "benign" clinical course of a congenital long QT syndrome (LQTS) simulated acute coronary event in an 85 year old woman who had a history of recurrent syncope accompanied by numerous severe traumatic events from childhood. Her daughter died suddenly. LQTS was diagnosed on the basis of characteristic ECG findings, including a permanently prolonged QT interval, typical dynamic T-wave changes, and runs of torsades de pointes.