Virtual screening of antibacterial compounds by similarity search of Enoyl-ACP reductase (FabI) inhibitors.

Antibiotic resistance is an alarming issue, as multidrug-resistant bacteria are growing worldwide, hence the decrease of therapeutic potential of available antibiotic arsenal. Among these bacteria, was pointed by the WHO in the pathogens list to be prioritized in drug development. We report the use of chemical similarity models for the virtual screening of new antibacterial with structural similarity to known inhibitors of FabI.