Publications by authors named "Leonardo R Leggieri"
The induction of CYP1A activity (EROD) and protein expression was compared in liver and gills of rainbow trout from a stream polluted with crude oil, and through laboratory exposures to 1% and 5% of water accommodated fraction of the crude oil (WAF) for 1 and 4 days. Gills EROD increased 1.6-2.
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- A study examined the effects of recreational mushing on adult sled dogs in North Patagonia, focusing on changes in creatinine kinase (CK), gastrin, and oxytocin levels.
- Significant increases in CK were noted during the winter, but levels returned to normal post-season, while gastrin levels remained low and stable.
- A slight increase in oxytocin (23%) after mushing suggests possible activation of the dogs' brain reward system, though no muscle damage or gastrin alterations were observed.
Effects of sequential exposure to water accommodated fraction of crude oil and chlorpyrifos on molecular and biochemical biomarkers in rainbow trout.
Comp Biochem Physiol C Toxicol Pharmacol
October 2018
Fish can be simultaneously or sequentially exposed to various kinds of pollutants, resulting in combined effects. Polycyclic aromatic hydrocarbons induce cytochrome P450 monooxygenase 1A (CYP1A) expression, which catalyzes the conversion of the organophosphorus insecticide chlorpyrifos (CPF) into its most active derivative, CPF-oxon. CPF-oxon inhibits CYP1A and other enzymes, including carboxylesterases (CEs) and acetylcholinesterase (AChE).
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