Publications by authors named "Leonardo Pulido"
Article Synopsis
- Melanoma is the most aggressive skin cancer with rising incidence and mortality rates, yet certain genetic variants (like p.R24P and p.A148T) associated with its development haven't been studied in Colombia.
- The study included 85 melanoma patients and 166 healthy controls, using HRM-qPCR and Sanger sequencing to detect gene variants.
- Results indicated that specific polymorphisms were not associated with melanoma susceptibility in the Colombian population, suggesting the need for more research on genetic interactions and additional variants.
Introduction: Mutations in the BRAF, NRAS, and C-KIT genes have been associated with the histopathological characteristics of melanoma. Likewise, the incidence of each of these subtypes changes according to the geographical origin of the population analyzed.
Objective: To determine the mutation frequency in exons 11 and 15 of the BRAF gene, exons 1 and 2 of the NRAS gene, and exons 11, 13, and 17 of the C-KIT gene and to relate it with histological subtypes in patients from a region with high levels of ultraviolet radiation.