Publications by authors named "Leonardo Paes da Silva"
Quantum mechanical, molecular docking, molecular dynamics, ADMET and antiproliferative activity on (Y strain) of chalcone ()-1-(2-hydroxy-3,4,6-trimethoxyphenyl)-3-(3-nitrophenyl)prop-2-en-1-one derived from a natural product.
Maria Geysillene Castro Matos Leonardo Paes da Silva Francisco Wagner Queiroz Almeida-Neto Emanuelle Machado Marinho Ramon Róseo Paula Pessoa Bezerra de Menezes Hélcio Silva Dos Santos Emmanuel Silva Marinho
Phys Chem Chem Phys
February 2022
Article Synopsis
- Recent research has focused on chalcones as potential new therapies, assessing their antiproliferative effects against Chagas' causative agent with promising results showing effectiveness at various concentrations.
- The studied chalcone exhibited a mechanism of action linked to mitochondrial damage and showed stronger affinity for the target enzyme cruzain than BZN, indicating its potential as an effective and less toxic treatment option.
Antioxidant and anticholinesterase activities of amentoflavone isolated from (Gardner) Engl. through and chemical-quantum studies.
Lucas Soares Frota Daniela Ribeiro Alves Márcia Machado Marinho Leonardo Paes da Silva Francisco Wagner de Queiroz Almeida Neto Emmanuel Silva Marinho
J Biomol Struct Dyn
March 2023
popularly known as batiputá, is a tree species easily found in the coastal part of northeastern Brazil. Its leaves are rich in biflavonoids, its major compound being amentoflavone. Biflavonoids are well studied due to their high antioxidant capacity.
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