Publications by authors named "Leonardo Osbourne Lai de Souza"
Article Synopsis
- Aging is associated with functional decline and mitochondrial dysfunction, largely due to decreased NAD levels and increased activity of the enzyme CD38.
- Research indicates that inhibiting CD38 can improve mitochondrial function in various tissues, but its specific impact on NAD levels and metabolism in the aging brain is still unclear.
- This study reveals that while CD38 does not affect overall NAD levels or mitochondrial oxygen consumption in aging brains, it plays a crucial role in regulating hydrogen peroxide production related to mitochondrial function, suggesting a new link between CD38 and brain energy metabolism in aging.
Obesity-related type II diabetes (diabesity) has increased global morbidity and mortality dramatically. Previously, the ancient drug salicylate demonstrated promise for the treatment of type II diabetes, but its clinical use was precluded due to high dose requirements. In this study, we present a nitroalkene derivative of salicylate, 5-(2-nitroethenyl)salicylic acid (SANA), a molecule with unprecedented beneficial effects in diet-induced obesity (DIO).
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