Publications by authors named "Leonardo Lima-Santos"
Klebsiella pneumoniae is a Gram-negative bacterium responsible for severe cases of nosocomial pneumonia. During the infectious process, both neutrophils and monocytes migrate to the site of infection, where they carry out their effector functions and can be affected by different patterns of cell death. Our data show that clinical strains of K.
View Article and Find Full Text PDFABCB1 and ABCC1-like transporters in immune system cells from sea urchins Echinometra lucunter and Echinus esculentus and oysters Crassostrea gasar and Crassostrea gigas.
Luis Fernando Marques-Santos Hélène Hégaret Leonardo Lima-Santos Fernando Ramos Queiroga Patricia Mirella da Silva
Fish Shellfish Immunol
November 2017
Article Synopsis
- ABC transporters are linked to the multixenobiotic resistance phenotype (MXR), which helps reduce the toxicity of foreign substances in cells.
- The study analyzed the activity of two specific ABC transporters, ABCB1 and ABCC1, in immune cells from sea urchins and oysters collected from Brazil and France, to understand their potential roles in marine invertebrate immunity.
- Results indicated that ABCC1-like activity is present in all examined immune cells, while ABCB1-like activity may only exist in certain sea urchin cells, highlighting differences in transporter function across species and cell types.
Enterococcus faecium is a frequently antibiotic-resistant opportunistic pathogen that is commonly recovered from hospitalized patients. The genetic organization of the dnaK operon was analyzed and was shown to consist of at least four heat shock genes, hrcA-grpE-dnaK-dnaJ. The dnaK/J intergenic region was 140 bp shorter than in E.
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