Publications by authors named "Leonardo J Mejia-Marin"
Background And Aims: Pediatric acute lymphoblastic leukemia (ALL) survival rates in low- and middle-income countries are lower due to deficiencies in multilevel factors, including access to timely diagnosis, risk-stratified therapy, and comprehensive supportive care. This retrospective study aimed to analyze outcomes for pediatric ALL at 16 centers in Mexico.
Methods: Patients <18 years of age with newly diagnosed B- and T-cell ALL treated between January 2011 and December 2019 were included.
Article Synopsis
- The incidence of total anomalous pulmonary venous connection (TAPVC) varies significantly between Caucasian (2.5/100,000) and Hispanic populations (19.8/100,000) and the study aims to identify maternal factors influencing TAPVC development.
- In the study, 55 mother-child pairs with TAPVC were compared to 152 healthy pairs, revealing that mothers of TAPVC children had more pregnancies and higher pre-pregnancy BMI, indicating a risk factor.
- The conclusion emphasizes that maternal obesity is linked to a higher risk of TAPVC in children within the Mexican population, highlighting the importance of maternal health before pregnancy.
Pallister-Killian syndrome is caused by a tetrasomy 12p mosaicism and is characterized by facial dysmorphism, pigmentary skin anomalies, congenital heart defects, diaphragmatic hernia, epilepsy and mental retardation. The diagnosis is complex as the cytogenetic analysis in blood is usually normal, requiring karyotyping in other tissues, therefore the clinical suspicion is critical to guide the diagnostic tests and the patient requires an interdisciplinary clinical evaluation regarding the several manifestation of the syndrome. W e present the case of a Mexican mestizo female patient of 4 years of age referred by psychomotor delay and cleft palate; the clinical multidisciplinary evaluation demonstrated characteristics corresponding to the Pallister-Killian syndrome.
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