α-amyrin-loaded nanocapsules produce selective cytotoxic activity in leukemic cells.

Introduction: Amyrins are triterpenes that have attractive pharmacological potential; however, their low water solubility and erratic stomach absorption hinders their use as a drug. The aim of this paper was to develop a novel α-amyrin-loaded nanocapsule for intestinal delivery and evaluate, preliminarily, its cytotoxic ability against leukemic cells.

Material And Methods: Five nanocapsule formulations were designed by the solvent displacement-evaporation method.