Distinct mechanisms of type 3 secretion system recognition control LTB4 synthesis in neutrophils and macrophages.

Leukotriene B4 (LTB4) is an inflammatory lipid produced in response to pathogens that is critical for initiating the inflammatory cascade needed to control infection. However, during plague, Yersinia pestis inhibits the timely synthesis of LTB4 and subsequent inflammation. Using bacterial mutants, we previously determined that Y.

Distinct Mechanisms of Type 3 Secretion System Recognition Control LTB Synthesis in Neutrophils versus Macrophages.

Leukotriene B4 (LTB) is critical for initiating the inflammatory cascade in response to infection. However, colonizes the host by inhibiting the timely synthesis of LTB and inflammation. Here, we show that the bacterial type 3 secretion system (T3SS) is the primary pathogen associated molecular pattern (PAMP) responsible for LTB production by leukocytes in response to and , but synthesis is inhibited by the Yop effectors during interactions.