Publications by authors named "Leonardo Beltran Angarita"
Background And Aims: Diarrhoea has a significant health impact and requires accurate diagnostic approaches, despite the limitations of many existing methods. This review examines various molecular techniques aimed at facilitating the rapid diagnosis of diarrhoeal diseases caused by bacterial, viral and parasitic pathogens.
Methods: A comprehensive systematic literature review was conducted using six prestigious databases, including WOS, Scopus, Science Direct, Embase, PubMed and LILACS Plus.
An updated examination of the perception of barriers for pharmacogenomics implementation and the usefulness of drug/gene pairs in Latin America and the Caribbean.
Front Pharmacol
May 2023
Article Synopsis
- Pharmacogenomics (PGx) is a growing field in developing countries, particularly in Latin America and the Caribbean (LAC), but research and information are limited, making it challenging to apply findings across diverse populations.
- The study reviewed PGx knowledge among the LAC scientific community, identified barriers to its clinical use, and surveyed 106 professionals to evaluate these obstacles, revealing that the primary barrier is the lack of guidelines for implementing PGx in practice.
- Despite these challenges, LAC has contributed 3.44% of global PGx publications and identified gene/drug pairs, such as tamoxifen and clopidogrel, as significant for improving genomic medicine responses, although cost-effectiveness concerns remain a critical issue.
Article Synopsis
- A study compared the effectiveness of conventional Methadone Maintenance Treatment (MMT) and a genetically-informed approach using the 516G>T polymorphism in determining methadone dosage for heroin addiction treatment over 12 weeks.* -
- Results showed that both treatment groups had similar rates of heroin use reduction and quality of life improvements, with 16% of the control group and 8% of the genetic group reporting heroin use by the study's end.* -
- Findings suggest that using genetic markers to tailor methadone doses may lower the required dosage, potentially reducing treatment costs without compromising treatment results or safety.*
Surveillance of the Antimicrobial Resistance Rates of Helicobacter pylori Ten Years Later in the Western Central Region, Colombia.
Dig Dis
July 2020
Background: Helicobacter pylori is a bacterium associated with gastroduodenal disease and gastric cancer. Empirical therapy in the treatment of H. pylori infection increases the risk of apparition of antimicrobial drug resistance.
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