DLK1-DIO3 region as a source of tumor suppressor miRNAs in papillary thyroid carcinoma.

Background: In previous studies, we demonstrated the downregulation of several miRNAs from the DLK1-DIO3 genomic region in papillary thyroid carcinoma (PTC). Due to the large number of miRNAs within this region, the individual contribution of these molecules to PTC development and progression remains unclear.

Objective: In this study, we aimed to clarify the contribution of DLK1-DIO3-derived miRNAs to PTC.