Publications by authors named "Leonardo A Ciufo"
Environ Pollut
December 2023
Article Synopsis
- Polycyclic aromatic hydrocarbons (PAHs), especially benzo [a]pyrene (BaP), are carcinogenic compounds found in tobacco smoke, affecting mammals through a pathway involving cytochrome P450 (CYP1A1), which is not present in C. elegans (roundworms).
- In C. elegans, BaP exposure leads to a decrease in lysosomal neutral lipids and the deletion of the cyp-35A2 gene increases neutral lipid metabolism.
- A dual-labelled reporter strain (cyp-35A2:mCherry; unc-47:GFP) has been developed to identify key regulators (elt-2, nhr-49, fos-1) of BaP metabolism
