The influence of water turbulence on surface deformations and the gas transfer rate across an air-water interface.

We present experimental results of a study on oxygen transfer rates in a water channel facility with varying turbulence inflow conditions set by an active grid. We compare the change in gas transfer rate with different turbulence characteristics of the flow set by four different water channel and grid configurations. It was found that the change in gas transfer rate correlates best with the turbulence intensity in the vertical direction.

Are lexical representations graded or discrete?

Most research on mental lexical representations (lemmas) assumes they are discrete and correspond in number to a word's number of distinct meanings. Thus, homophones (), whose meanings are unrelated, have separate lemmas for each meaning (one for , another for ), whereas polysemes (), whose senses are related, have shared lemmas (the same lemma for and ). However, most aspects of cognition are thought to be graded, not discrete; could lemmas be graded too? We conducted a preregistered picture-word interference study with pictures of words whose meanings ranged from unrelated (homophones) to very related (regular polysemes).

Understanding and Addressing Older Adults' Loneliness: The Social Relationship Expectations Framework.

Loneliness is an experience resulting from a perceived discrepancy between expected and actual social relationships. Although this discrepancy is widely considered the "core mechanism" of loneliness, previous research and interventions have not sufficiently addressed what older adults specifically expect from their social relationships. To address this gap and to help situate research on older adults' loneliness within broader life span developmental theories, we propose a theoretical framework that outlines six key social relationship expectations of older adults based on research from psychology, gerontology, and anthropology: availability of social contacts, receiving care and support, intimacy and understanding, enjoyment and shared interests, generativity and contribution, and being respected and valued.

Disagreement, justification, and equitable moral judgments: A brief training study.

Although theorists agree that social interactions play a major role in moral development, previous research has not experimentally assessed how specific features of social interactions affect children's moral judgments and reasoning. The current study assessed two features: disagreement and justification. In a brief training phase, children aged 4-5.

Genetic syndromes with diabetes: A systematic review.

Previous reviews and clinical guidelines have identified 10-20 genetic syndromes associated with diabetes, but no systematic review has been conducted to date. We provide the first comprehensive catalog for syndromes with diabetes mellitus. We conducted a systematic review of MEDLINE, Embase, CENTRAL, PubMed, OMIM, and Orphanet databases for case reports, case series, and observational studies published between 1946 and January 15, 2020, that described diabetes mellitus in adults and children with monogenic or chromosomal syndromes.

Young children conform more to norms than to preferences.

As members of cultural groups, humans continually adhere to social norms and conventions. Researchers have hypothesized that even young children are motivated to act conventionally, but support for this hypothesis has been indirect and open to other interpretations. To further test this hypothesis, we invited 3.

Why Does Awe Have Prosocial Effects? New Perspectives on Awe and the Small Self.

Awe is an emotional response to stimuli that are perceived to be vast (e.g., tall trees, sunsets) and that defy accommodation by existing mental structures.

Comparative toxicokinetics and tissue distribution of prothioconazole and prothioconazole-desthio in Chinese lizards (Eremias argus) and transcriptional responses of metabolic-related genes.

Prothioconazole (PTC) is a widely used triazolinthione fungicide with low toxicity and short residual period. However, its desulfurization metabolite, prothioconazole-desthio (PTC-d), is more persistent and has higher toxicity in terrestrial animals. In this study, the toxicokinetics (TK) and tissue distribution of PTC and PTC-d in Chinese lizards (Eremias argus) were measured following single oral dose (100 mg kg body weight) treatments.

Lying, negligence, or lack of knowledge? Children's intention-based moral reasoning about resource claims.

In a hidden inequality context, resource allocators and resource recipients are unaware that an unknowingly advantaged recipient possesses resources. The present study presented children aged 3-13 years (N = 121) with a hidden inequality vignette involving an accidental transgression in which one resource claimant, who unknowingly possessed more resources than another claimant, made an "unintentional false claim" to resources. This unintentional false claim resulted in depriving another recipient of needed resources.

Brain-to-speech decoding will require linguistic and pragmatic data.

Objective: Advances in electrophysiological methods such as electrocorticography (ECoG) have enabled researchers to decode phonemes, syllables, and words from brain activity. The ultimate aspiration underlying these efforts is the development of a brain-machine interface (BMI) that will enable speakers to produce real-time, naturalistic speech. In the effort to create such a device, researchers have typically followed a bottom-up approach whereby low-level units of language (e.

Integration of Nanomaterials into Three-Dimensional Vertical Architectures.

A novel layer-by-layer three-dimensional (3D) architecture allowing one to expand device fabrication in the vertical direction and integrating functional nanomaterials is presented by emulating civil engineering. The architecture uses SU-8 pillars as structural columns, which support multiple horizontal suspended thin films. The films then serve as platforms for the integration of nanomaterials and nanodevices.

Daily stock index return for the Canadian, UK, and US equity markets, compiled by Morgan Stanley Capital International, obtained from Datastream.

The data presented in this article are related to the research article entitled "Testing and comparing the performance of dynamic variance and correlation models in value-at-risk estimation. North American Journal of Economics and Finance, 40, 116-135. doi:10.

Theory of Mind and Resource Allocation in the Context of Hidden Inequality.

In many situations, children evaluate straightforward resource inequalities as unfair. It remains unclear, however, how children interpret (i.e.

Of Papers and Pens: Polysemes and Homophones in Lexical (mis)Selection.

Every word signifies multiple senses. Many studies using comprehension-based measures suggest that polysemes' senses (e.g.

Mucus barrier-triggered disassembly of siRNA nanocarriers.

The mucus overlying mucosal epithelial surfaces presents not only a biological barrier to the penetration of potential pathogens, but also therapeutic modalities including RNAi-based nanocarriers. Movement of nanomedicines across the mucus barriers of the gastrointestinal mucosa is modulated by interactions of the nanomedicine carriers with mucin glycoproteins inside the mucus, potentiated by the large surface area of the nanocarrier. We have developed a fluorescence activation-based reporter system showing that the interaction between polyanionic mucins and the cationic chitosan/small interfering RNA (siRNA) nanocarriers (polyplexes) results in the disassembly and consequent triggered release of fluorescent siRNA.

Establishment and characterization of esophageal squamous cell carcinoma patient-derived xenograft mouse models for preclinical drug discovery.

The purpose of this study was to establish and characterize patient-derived esophageal squamous cell carcinoma xenograft (PDECX) mice for utilization in antitumor drug discovery. A total of 96 esophageal squamous cell carcinoma (ESCC) tissues from Chinese patients were transplanted subcutaneously into immunodeficient mice. Histology, EGFR, K-ras, B-raf, and PIK3CA mutations, and HER2 gene amplifications were analyzed in both patient tumors and mouse xenograft tissues using immunohistochemistry, mutant-enriched liquid chip sequencing and fluorescence in situ hybridization assays, respectively.

Spatial configuration and composition of charge modulates transport into a mucin hydrogel barrier.

The mucus barrier is selectively permeable to a wide variety of molecules, proteins, and cells, and establishes gradients of these particulates to influence the uptake of nutrients, the defense against pathogens, and the delivery of drugs. Despite its importance for health and disease, the criteria that govern transport through the mucus barrier are largely unknown. Studies with uniformly functionalized nanoparticles have provided critical information about the relevance of particle size and net charge for mucus transport.

A microfluidic in vitro system for the quantitative study of the stomach mucus barrier function.

In the stomach, a layer of gastric mucus protects the epithelial cells of the stomach wall against damage by the acidic digestive juices in the gastric lumen. Despite considerable research, the biophysical mechanisms for this acid barrier are not understood. We present an in vitro microfluidic tool to characterize the stomach acid barrier, in which purified mucin polymers are "secreted" against an acidic zone on chip, mimicking the in vivo secretion of gastric mucus into an acidic stomach lumen.

A microfluidics approach towards high-throughput pathogen removal from blood using margination.

Sepsis is an adverse systemic inflammatory response caused by microbial infection in blood. This paper reports a simple microfluidic approach for intrinsic, non-specific removal of both microbes and inflammatory cellular components (platelets and leukocytes) from whole blood, inspired by the invivo phenomenon of leukocyte margination. As blood flows through a narrow microchannel (20 × 20 µm), deformable red blood cells (RBCs) migrate axially to the channel centre, resulting in margination of other cell types (bacteria, platelets, and leukocytes) towards the channel sides.

Pinched flow coupled shear-modulated inertial microfluidics for high-throughput rare blood cell separation.

Blood is a highly complex bio-fluid with cellular components making up >40% of the total volume, thus making its analysis challenging and time-consuming. In this work, we introduce a high-throughput size-based separation method for processing diluted blood using inertial microfluidics. The technique takes advantage of the preferential cell focusing in high aspect-ratio microchannels coupled with pinched flow dynamics for isolating low abundance cells from blood.

Massively parallel concentration device for multiplexed immunoassays.

A massively parallel nanofluidic concentration device array for multiplexed and high-throughput biomolecule detection is demonstrated. By optimizing the microchannel/nanojunction design and channel conductivity, an array of up to 128 nanofluidic concentration devices were fabricated. Operation of the entire array requires only one inlet and one outlet reservoir, with the application of a single operational voltage bias across them.

Amplified electrokinetic response by concentration polarization near nanofluidic channel.

Ion concentration polarization is the fundamental transport phenomenon that occurs near ion-selective membranes, but this important membrane phenomenon has been poorly understood due to theoretical and experimental challenges. Here, we report the first direct measurements of detailed flow and electric potential profiles within and near the depletion region. This work is an important step toward a full characterization of this coupled transport problem.