The risk of exposure to diagnostic ultrasound in postnatal subjects: nonthermal mechanisms.

This review examines the nonthermal physical mechanisms by which ultrasound can harm tissue in postnatal patients. First the physical nature of the more significant interactions between ultrasound and tissue is described, followed by an examination of the existing literature with particular emphasis on the pressure thresholds for potential adverse effects. The interaction of ultrasonic fields with tissue depends in a fundamental way on whether the tissue naturally contains undissolved gas under normal physiologic conditions.

Threshold estimation of ultrasound-induced lung hemorrhage in adult rabbits and comparison of thresholds in mice, rats, rabbits and pigs.

The objective of this study was to assess the threshold and superthreshold behavior of ultrasound (US)-induced lung hemorrhage in adult rabbits to gain greater understanding about species dependency. A total of 99 76 +/- 7.6-d-old 2.

Superthreshold behavior of ultrasound-induced lung hemorrhage in adult rats: role of pulse repetition frequency and pulse duration.

Objective: The purpose of this study was to enhance the findings of an earlier ultrasound-induced lung hemorrhage study (Ultrasound Med Biol 2003; 29:1625-1634) that estimated pressure thresholds as a function of pulse duration (PD: 1.3, 4.4, 8.

Superthreshold behavior of ultrasound-induced lung hemorrhage in adult rats: role of pulse repetition frequency and exposure duration revisited.

Objective: The purpose of this study was to augment and reevaluate the ultrasound-induced lung hemorrhage findings of a previous 5 x 3 factorial design study (Ultrasound Med Biol 2001; 27:267-277) that evaluated the role of pulse repetition frequency (PRF: 25, 50, 100, 250, and 500 Hz) and exposure duration (ED; 5, 10, and 20 s) on ultrasound-induced lung hemorrhage at an in situ (at the pleural surface) peak rarefactional pressure [pr(in situ)] of 12.3 MPa; only PRF was found to be significant. However, saturation (response plateau) due to the high pr(in situ) might have skewed the results.

Effect of contrast agent on the incidence and magnitude of ultrasound-induced lung hemorrhage in rats.

Objective: To test the hypothesis that inertial cavitation in the vasculature of the lung is not the physical mechanism responsible for ultrasound-induced lung hemorrhage.

Methods: A factorial design was used to study the effects of two types of injected agents (IA; 0.25 ml per rat of saline or Optison given intravenously) and two levels of pulsed ultrasound exposure (UE; in situ peak rarefactional pressures of 2.

Threshold estimates and superthreshold behavior of ultrasound-induced lung hemorrhage in adult rats: role of pulse duration.

The study objective was to estimate the pressure threshold (ED(05), effective dose, or in situ peak rarefactional pressure associated with 5% probability of lesions) of ultrasound (US)-induced lung hemorrhage as a function of pulse duration (PD) in adult rats. A total of 220 10- to 11-week-old 250-g female Sprague-Dawley rats (Harlan) were randomly divided into 20 ultrasonic exposure groups (10 rats/group) and one sham group (20 rats). The 20 ultrasonic exposure groups (2.

Effect of pulse polarity and energy on ultrasound-induced lung hemorrhage in adult rats.

The objective of this study was to further assess the role of inertial cavitation in ultrasound-induced lung hemorrhage by examining the effect of pulse polarity at a common in situ (at the lung surface) peak rarefactional pressure [pr(in situ)] and at a common in situ pulse intensity integral (PII(in situ)). A total of 60 rats was divided into three experimental groups of 20 animals per group and randomly exposed to pulsed ultrasound. The groups were exposed as follows: Group 1 to 0 degree polarity pulses (compression followed by rarefraction) at a pr(in situ) of 3.

Superthreshold behavior and threshold estimation of ultrasound-induced lung hemorrhage in pigs: role of age dependency.

Age-dependent threshold and superthreshold behavior of ultrasound-induced lung hemorrhage were investigated with 116 2.1 +/- 0.3-kg neonate crossbred pigs (4.

The effect of pulsed ultrasound on mandibular distraction.

This study evaluated the effect of pulsed ultrasound on tissue repair and bone growth during mandibular osteodistraction. Twenty-one rabbits were divided into three groups of 7. The distraction started 72 h after surgically severing both sides of the mandible and proceeded at a rate of 1.

Arrhythmias in rat hearts exposed to pulsed ultrasound after intravenous injection of a contrast agent.

Objective: To develop an animal model suitable for characterizing electrocardiographic arrhythmias in hearts exposed to ultrasound after injection of a microbubble contrast agent.

Methods: Conduction complex and heart lesion data were recorded from 20 rats that received intravenous injections of 0.25 mL of a contrast agent and were exposed to pulsed ultrasound (frequency, 3.

Attenuation coefficient and propagation speed estimates of intercostal tissue as a function of pig age.

Attention coefficient and propagation speed of intercostal tissues were estimated from chest walls removed postmortem (pm) from 15 5.3+/-2.3-day-old, 19 31+/-6-day-old, and 15 61+/-3-day-old crossbred pigs.

Attenuation coefficient and propagation speed estimates of rat and pig intercostal tissue as a function of temperature.

Attenuation coefficient and propagation speed of intercostal tissues were estimated as functions of temperature (22, 30, and 37 degrees C) from fresh chest walls from eight 10- to 11-week-old female Sprague-Dawley (SD) rats, eight 21- to 24-week-old female Long-Evans (LE) rats, and ten 6- to 10-week-old mixed sex Yorkshire (York) pigs. The primary purpose of the study was to estimate the temperature dependence of the intercostal tissue's attenuation coefficient so that accurate estimates of the in situ (at the pleural surface) acoustic pressure levels could be made for our ultrasound-induced lung hemorrhage studies. The attenuation coefficient of intercostal tissue for both species was independent of the temperature at the discrete frequencies of 3.

Ultrasound-induced lung hemorrhage: role of acoustic boundary conditions at the pleural surface.

In a previous study [J. Acoust. Soc.