Publications by authors named "Leoma Bere"
Article Synopsis
- Myeloid cells are abundant in glioblastoma (GBM) and exist in various forms with different activation states, but there’s limited understanding of how the tumor microenvironment (TME) affects their behavior.
- Researchers used advanced imaging techniques to analyze and map these myeloid cell populations within the GBM TME, revealing that their distribution is influenced by factors like tissue hypoxia and specific signaling molecules.
- The study found that the organization of these myeloid cells in certain tumor areas corresponds to patient survival rates, providing important insights into how these cells may impact clinical outcomes in GBM patients.
Natural killer (NK) cells can kill infected or transformed cells via a lytic immune synapse. Diseased cells may exhibit altered mechanical properties but how this impacts NK cell responsiveness is unknown. We report that human NK cells were stimulated more effectively to secrete granzymes A and B, FasL (also known as FasLG), granulysin and IFNγ, by stiff (142 kPa) compared to soft (1 kPa) planar substrates.
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