Publications by authors named "Leok Lim Lau"

Article Synopsis
  • Surgical treatment for cancer patients with epidural spinal cord compression has evolved significantly, particularly with the rise of minimally invasive surgical (MIS) techniques and separation surgery over the past 17 years.
  • A study of 383 patients showed increasing numbers of surgeries performed and a notable reduction in blood loss and transfusion rates, with those treated more recently experiencing better neurological improvements and mobility.
  • Despite these advancements in surgical technique and patient outcomes, overall survival rates remained unchanged, highlighting the need for a multidisciplinary approach to patient management.
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Study Design: Retrospective Exact Matched case-control study.

Objectives: Surgical treatment delay in AIS due to family preferences is common. This study aims to quantify the increase in risks as the Cobb angle increases and provide a Quantifiable Risk Reference Table that can be utilized for counseling.

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Study Design: Single-center retrospective review of outcomes among three surgical techniques in the treatment of thoracic idiopathic scoliosis (T-AIS) with a follow-up of at least 5 years.

Objective: To investigate how outcomes compare in video-assisted anterior thoracic instrumentation (VATS), all hooks/hook-pedicle screw hybrid instrumentation (HHF), and all pedicle screw instrumentation (PSF) techniques for T-AIS.

Summary Of Background Data: Studies comparing outcomes for anterior versus posterior fusion for T-AIS are few and with short follow-up.

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Background Context: Ossification of the posterior longitudinal ligament (OPLL) is a progressive, debilitating disease most commonly affecting the cervical spine. When compared to other degenerative pathologies, OPLL procedures carry a significantly higher risk of complications owing to increased case complexity and technical difficulties. Most previous studies have focused on functional outcomes and few have reported on risk factors for postoperative complications in OPLL patients.

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Introduction: During the Coronavirus disease 2019 outbreak, while healthcare systems and hospitals are diverting their resources to combat the pandemic, patients who require spinal surgeries continue to accumulate. The aim of this study is to describe a novel hospital capacity versus clinical justification triage score (CCTS) to prioritize patients who require surgery during the "new normal state" of the COVID-19 pandemic.

Methodology: A consensus study using the Delphi technique was carried out among clinicians from the Orthopaedic Surgery, Neurosurgery, and Anaesthesia departments.

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Study Design: Retrospective cohort study.

Objective: This study aimed to identify risk factors that predict lumbar curve adding-on in patients who had selective thoracic fusion.

Summary Of Background Data: Selective thoracic fusion offers deformity correction of Lenke 1 and 2 thoracic curves and maintains lumbar range of movement.

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Study Design: Retrospective cohort study.

Purpose: To evaluate the incidence and presentation of symptomatic failures (SFs) after metastatic spine tumor surgery (MSTS). To identify the associated risk factors.

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Unlabelled: MINI: This is a long-term prospective cohort study comparing the radiographic outcomes of anterior versus posterior instrumentation for Lenke 5 adolescent idiopathic scoliosis. Both approaches were comparable in terms of radiographic outcomes up to 10 years. The posterior approach is more prone to developing proximal junctional kyphosis.

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Study Design: A retrospective design.

Objective: We aim to report our experience with multimodal intraoperative neuromonitoring (IONM) in metastatic spine tumor surgery (MSTS).

Summary Of Background Data: IONM is considered as standard of care in spinal deformity surgeries.

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Study Design: A single-center, retrospective cohort study.

Objective: To predict patient-reported outcomes (PROs) using preoperative health-related quality-of-life (HRQoL) scores by quantifying the correlation between them, so as to aid selection of surgical candidates and preoperative counselling.

Methods: All patients who underwent single-level elective lumbar spine surgery over a 2-year period were divided into 3 diagnosis groups: spondylolisthesis, spinal stenosis, and disc herniation.

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Purpose: To describe normal variations in sagittal spinal radiographic parameters over an interval period and establish physiological norms and guidelines for which these images should be interpreted.

Methods: Data were prospectively collected from a continuous series of adult patients with first-episode mild low back pain presenting to a single institution. The sagittal parameters of two serial radiographic images taken 6-months apart were obtained with the EOS slot scanner.

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Article Synopsis
  • * The study combined a data review and a prospective analysis to identify risk factors for pressure injuries, considering various patient and surgical characteristics.
  • * Findings revealed a 23.0% prevalence of pressure injuries post-surgery, with previous skin issues and myelopathy identified as notable risk factors.
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Study Design: A cross-sectional study of prospectively collected data.

Objective: To compare lumbar spine alignment in six common postures, and estimate loss in range of motion (ROM) relative to standing.

Summary Of Background Data: Ideal position for fusion of lumbar spine remains unknown.

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Study Design: This is a retrospective cohort comparative study of all patients who underwent instrumented spine surgery at a single institution.

Objective: To compare the rate of surgical site infection (SSI) between the treatment (vancomycin) and the control group (no vancomycin) in patients undergoing instrumented spine surgery.

Summary Of Background Data: SSI after spine surgery is a dreaded complication associated with increased morbidity and mortality.

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Background Context: Knowledge of sagittal radiographic parameters in adolescent idiopathic scoliosis (AIS) patients has not yet caught up with our understanding of their roles in patients with adult spinal deformity. It is likely that more emphasis will be placed in restoring sagittal parameters for AIS patients in the future. Therefore, we need to understand how these parameters may vary in AIS to facilitate management plans.

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Background Context: Adult spinal deformity correction sometimes involves long posterior pedicle screw constructs extending from the lumbosacral spine to the thoracic vertebra. As fusion obliterates motion and places supraphysiological stress on adjacent spinal segments, it is crucial to ascertain the ideal upper instrumented vertebra (UIV) to minimize risk of proximal junctional failure (PJF). The T10 vertebra is often chosen to allow bridging of the thoracolumbar junction into the immobile thoracic vertebrae on the basis that it is the lowest immobile thoracic vertebra strut by the rib cage.

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Background Context: Sitting spinal alignment is increasingly recognized as a factor influencing strategy for deformity correction. Considering that most individuals sit for longer hours in a "slumped" rather than in an erect posture, greater understanding of the natural sitting posture is warranted.

Purpose: This study aimed to investigate the differences in sagittal spinal alignment between two common sitting postures: a natural, patient-preferred posture; and an erect, investigator-controlled posture that is commonly used in alignment studies.

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Article Synopsis
  • - A retrospective study of 84 patients over 14 years examined the effects of different treatment methods for deep spine infections, comparing antibiotics alone, antibiotics plus debridement, and antibiotics plus debridement with instrumentation.
  • - The study found no significant differences in reoperation or reinfection rates among the treatment groups, indicating that adding instrumentation does not negatively impact patient outcomes.
  • - Those who received spinal instrumentation had a lower in-hospital mortality rate compared to those treated with antibiotics alone, suggesting that instrumentation may be a safe option in managing spine infections.
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Background Context: The current prevailing school of thought in spinal deformity surgery is to restore sagittal balance with reference to the alignment of the spine when the patient is standing. This strategy, however, likely accounts for increased rates of proximal junctional failure.

Purpose: The purpose of this study was to investigate the differences between the spine in standing and sitting positions as these may elucidate reasons for deformity correction failure.

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Purpose: To determine the effect of preoperative embolization on intraoperative blood loss in surgery for metastatic spinal tumours stratified by tumour type, type of surgical approach and extent of surgery.

Methods: We retrospectively analysed 218 patients undergoing open surgery for metastatic spine tumours in our institution between 2005 and 2014. The cohort was divided to those who underwent preoperative embolization and those who did not.

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Intradural spinal cord abscesses especially in the cervical spine are a rare occurrence. We report a rare presentation of an intradural extramedullary abscess at the atlantoaxial level, initially misdiagnosed as an epidural collection. The patient presented with worsening quadriparesis preceded by a 2-week history of upper respiratory tract infection and neck pain.

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Introduction: Sports injuries in children and adolescent present a unique challenge to the physician. They are often seen for clinical conditions unique to their age group. This paper highlights the epidemiological aspect of sports-related overuse injuries in this age group.

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