Optimization of β-Lactam Dosing Regimens in Neonatal Infections: Continuous and Extended Administration versus Intermittent Administration.

Background And Objective: In neonates, β-Lactam antibiotics are almost exclusively administered by intermittent infusion. However, continuous or prolonged infusion may be more beneficial because of the time-dependent antibacterial activity. In this pharmacokinetic/pharmacodynamic simulation study, we aimed to compare treatment with continuous, extended and intermittent infusion of β-lactam antibiotics for neonates with infectious diseases.

The effect of individualized iron supplementation on iron status in Dutch preterm infants born between 32 and 35 weeks of gestational age: evaluation of a local guideline.

Objective: Iron deficiency (ID) and iron deficiency anemia (IDA) in early life are associated with adverse effects. Preterm infants are at risk for developing ID(A). Considering that not every preterm infant develops ID(A) and the potential risk of iron overload, indiscriminate iron supplementation in late preterm infants is debatable.

[A newborn with an abnormal position of both legs].

A baby was born with an abnormal position of both legs due to congenital genu recurvatum. This is a rare condition which can appear as an isolated deformity, but is also associated with other musculoskeletal anomalies and syndromes. The prognosis is generally good.

[A neonate with dark brown coloured buttocks and upper legs].

A neonate was seen by the pediatrician because of a well-defined macular hyperpigmentation of the skin in the genital area. The diagnosis 'giant congenital melanocytic nevi (CMN)' was made. This occurs in 1 of 20.