Racial/Ethnic Differences in Labor Outcomes with Prostaglandin Vaginal Inserts.

Objective: The aim of this study is to compare labor outcomes across race/ethnicity in women undergoing prostaglandin labor induction.

Methods: Secondary analysis of misoprostol vaginal insert (MVI) trial, a double-blind, randomized, control trial of 1,308 patients comparing sustained release vaginal inserts containing dinoprostone 10 mg and misoprostol 50 mcg (MVI 50) or 100 mcg (MVI 100).

Results: Achievement of active labor and induction failures were similar across race/ethnicity.

Women's attitudes regarding mode of delivery and cesarean delivery on maternal request.

Objective: To explore women's attitudes and beliefs regarding cesarean delivery and cesarean delivery on maternal request (CDMR).

Study Design: Anonymous questionnaires assessing patient demographics, knowledge, and attitudes about CDMR were distributed at the time of routine mid-trimester ultrasound appointment.

Results: Eight hundred thirty three out of 3929 (21.

Effects of maternal obesity on tissue concentrations of prophylactic cefazolin during cesarean delivery.

Objective: To estimate the adequacy of antimicrobial activity of preoperative antibiotics at the time of cesarean delivery as a function of maternal obesity.

Methods: Twenty-nine patients scheduled for cesarean delivery were stratified according to body mass index (BMI) category, with 10 study participants classified as lean (BMI less than 30), 10 as obese (BMI 30-39.9), and nine as extremely obese (BMI 40 or higher).

Cardiotocographic abnormalities associated with misoprostol and dinoprostone cervical ripening and labor induction.

Objective: To characterize the incidence and timing of cardiotocographic (CTG) abnormalities associated with misoprostol and dinoprostone vaginal inserts during labor induction.

Study Design: This was a secondary analysis of data collected during the misoprostol vaginal insert (MVI) trial, a multi-site, double-masked, randomized trial of women requiring cervical ripening before induction of labor. The timing, incidence and clinical outcomes associated with CTG abnormalities were analyzed among three study groups.

Retention of dinoprostone vaginal insert beyond 12 hours for induction of labor.

We evaluate the likelihood of cesarean delivery and identify risks of retaining a sustained-release dinoprostone vaginal insert beyond 12 hours. In a secondary analysis of outcomes, data were collected during a large, randomized trial comparing different sustained-release prostaglandin vaginal inserts for labor induction. Outcomes were compared between cases in whom the dinoprostone insert was removed early (within 12 hours) or late (12 to 24 hours).

Effects of maternal obesity on duration and outcomes of prostaglandin cervical ripening and labor induction.

Objective: To estimate the effect of maternal body mass index (BMI) on progress and outcomes of prostaglandin labor induction.

Methods: This study was a secondary analysis of data collected during the Misoprostol Vaginal Insert Trial, a multisite, double-blind, randomized trial of women requiring cervical ripening before induction of labor. The duration, characteristics, and outcomes of labor were analyzed after stratification by BMI categories.

Factors predicting successful labor induction with dinoprostone and misoprostol vaginal inserts.

Objective: To evaluate the maternal and pregnancy characteristics that independently predict successful induction of labor, defined as vaginal delivery.

Methods: The study was a secondary analysis of the data collected during the Misoprostol Vaginal Insert Trial, a multisite, double-blind, randomized trial of women requiring cervical ripening before induction of labor. The primary outcome was to estimate the maternal and pregnancy characteristics that independently predict successful induction of labor.

Patients' attitudes associated with cesarean delivery on maternal request in an urban population.

Objective: To explore patient attitudes related to cesarean delivery on maternal request (CDMR).

Study Design: Questionnaires were distributed to patients in mid-trimester. Questions assessed patient demographics, knowledge, perceived risks, and attitudes about CDMR.