Thirty-five years of the Department of Plastic Surgery and Burns Treatment at the University Hospital in Hradec Králové.

Background: The Department of Plastic Surgery and Burns Treatment was established as a part of the newly created 2nd Department of Surgery of Charles University, Medical Faculty and the University Hospital in Hradec Králové in 1985. Through modest beginnings, activities of the Department expanded up to full coverage of specialized care in plastic surgery within the region with almost one million inhabitants.

Aim: In this article, the most important events of several historical phases related to almost four decades are described.

Impact of Antibiotics Associated with the Development of Toxic Epidermal Necrolysis on Early and Late-Onset Infectious Complications.

Toxic epidermal necrolysis (TEN) is a rare disease, which predominantly manifests as damage to the skin and mucosa. Antibiotics count among the most common triggers of this hypersensitive reaction. Patients with TEN are highly susceptible to infectious complications due to the loss of protective barriers and immunosuppressant therapy.

Objective evaluation of the effect of autologous platelet concentrate on post-operative scarring in deep burns.

Introduction: The healing of grafted areas after surgical treatment of deep burns frequently generates mutilating scars, and rises the risk of subsequent scar hypertrophy. Scar assessment based on clinical evaluation is inherently subjective, which stimulates search for objective means of evaluation.

Objective: The aim of this study was to objectively evaluate the effect of using autologous platelet concentrate (APC) in combination with split thickness skin grafting (STSG) on scarring processes following surgery of deep burns as compared with application of STSG alone.

Suture-free anastomosis of the colon. Experimental comparison of two cyanoacrylate adhesives.

Background: We explored the potential of two cyanoacrylate tissue adhesives for constructing colonic anastomoses.

Method: The study involved 12 female domestic pigs. The animals were divided into two equal groups.

Human allogeneic keratinocytes cultured on acellular xenodermis: the use in healing of burns and other skin defects.

The tissue engineered skin should be composed of both dermal and epidermal layers. We combined cultured human allogeneic keratinocytes with acellular xenodermis prepared from pig xenografts. The resulting composite skin was termed recombined human/pig skin (RHPS), and could be cultured in both, undifferentiated and differentiated phenotype.