Association of willingness to use hormonal contraception with knowledge: A national survey.

Objective: To determine if willingness to use and concern with using hormonal contraception (HC) is associated with knowledge about HC.

Study Design: We conducted an online cross-sectional survey of self-identified women, US residents 18 and older using Amazon Mechanical Turk and ResearchMatch.org.

Association of body mass index on time to fetal expulsion for individuals undergoing medication abortion over 13 weeks gestational duration.

Objectives: This study aimed to examine the association of body mass index (BMI, kg/m) with time to fetal expulsion for individuals undergoing medication abortion over 13 weeks.

Study Design: This is a retrospective cohort study of singleton pregnancies undergoing medication abortion >13 weeks at a single academic medical center between 2020 and 2024. Our primary outcome was time to fetal expulsion.

Transcriptional profiling of mucus production in rhesus macaque endocervical cells under hormonal regulation†.

Objective: Endocervical mucus production is a key regulator of fertility throughout the menstrual cycle. With cycle-dependent variability in mucus quality and quantity, cervical mucus can either facilitate or block sperm ascension into the upper female reproductive tract. This study seeks to identify genes involved in the hormonal regulation of mucus production, modification, and regulation through profiling the transcriptome of endocervical cells from the non-human primate, the rhesus macaque (Macaca mulatta).

Common misperceptions and public knowledge about intrauterine devices among US-based online respondents.

Objectives: Misperceptions about intrauterine devices (IUDs) may dissuade potential users and public beliefs are not well understood. We sought to describe public knowledge of mechanism of action, failure rate, and IUD health risks. Secondary objectives included identifying inaccurate information and information sources about IUDs.

Effects of Virtual Reality Therapy Combined With Conventional Rehabilitation on Pain, Kinematic Function, and Disability in Patients With Chronic Neck Pain: Randomized Controlled Trial.

Background: Neck pain is a common condition that leads to neck motor dysfunction and subsequent disability, with a significant global health care burden. As a newly emerging tool, virtual reality (VR) technology has been employed to address pain and reduce disability among patients with neck pain. However, there is still a lack of high-quality studies evaluating the efficacy of VR therapy combined with conventional rehabilitation for patients with chronic neck pain, particularly in terms of kinematic function.

Transcriptional profiling of mucus production and modification in rhesus macaque endocervical cells under hormonal regulation.

Objective: Endocervical mucus production is a key regulator of fertility throughout the menstrual cycle. With cycle-dependent variability in mucus quality and quantity, cervical mucus can either facilitate or block sperm ascension into the upper female reproductive tract. This study seeks to identify genes involved in the hormonal regulation of mucus production, modification, and regulation through profiling the transcriptome of endocervical cells from the non-human primate, the Rhesus Macaque (Macaca mulatta).

Treatment of unfavorable bleeding patterns in contraceptive implant users: a randomized clinical trial of curcumin.

Background: Some users of the etonogestrel contraceptive implant experience bothersome bleeding, which can reduce contraceptive satisfaction and continuation. Few strategies exist to manage this bleeding. The exact mechanism of progestin-induced bleeding is unknown, but it is likely multifactorial (eg, impaired angiogenesis, "leaky" fragile vasculature, and inflammation).

Hormonal regulation of non-cystic fibrosis transmembrane conductance regulator ion channels in the endocervix.

Objective: To characterize ion channel expression and localization in the endocervix under different hormonal conditions using a nonhuman primate primary endocervical epithelial cell model.

Design: Experimental.

Setting: University-based, translational science laboratory.

Association between menstrual cycle length and covid-19 vaccination: global, retrospective cohort study of prospectively collected data.

Objectives: To identify whether covid-19 vaccines are associated with menstrual changes in order to address concerns about menstrual cycle disruptions after covid-19 vaccination.

Design: Global, retrospective cohort study of prospectively collected data.

Setting: International users of the menstrual cycle tracking application, Natural Cycles.

The effect of deliberate non-adherence to a norgestrel progestin-only pill: A randomized, crossover study.

Objectives: To estimate the effects on cervical mucus, ovarian activity and theoretical contraceptive protection of a 6-hour delay and of missing one norgestrel 0.075 mg progestogen-only pill.

Study Design: In a prospective, two-site, randomized, crossover study, healthy women aged 18 to 35 with BMI <32.

Mucus secretions from a conditionally reprogrammed primary endocervical cell culture.

Objective: To determine if the secretions collected from a conditionally reprogrammed primary endocervical cell culture are suitable surrogates for mucus studies.

Design: Experimental.

Setting: University research center.

Functional evaluation of the cystic fibrosis transmembrane conductance regulator in the endocervix†.

The cystic fibrosis transmembrane conductance regulator (CFTR) is an apical membrane chloride/bicarbonate ion channel in epithelial cells. Mutations in CFTR cause cystic fibrosis, a disease characterized by thickened mucus secretions and is associated with subfertility and infertility. CFTR function has been well characterized in vitro and in vivo in airway and other epithelia studies.

Mechanism of action of a 0.075 mg norgestrel progestogen-only pill 2. Effect on cervical mucus and theoretical risk of conception.

Objective: To evaluate the cervical mucus effects of a norgestrel 0.075 mg progestin-only contraceptive pill over a 28-day cycle.

Study Design: We recruited persons ages 18 to 35 with normal cycles at 2 US academic medical centers.

Mechanism of action of norgestrel 0.075 mg a progestogen-only pill. I. Effect on ovarian activity.

Objective: To explore the effect on ovarian activity and ovulation of 28 days of correct daily use of a progestogen-only pill containing norgestrel 0.075 mg.

Study Design: We performed a prospective, randomized, crossover study at 2 US sites, recruiting healthy women of reproductive age to use norgestrel 0.

Comparing endocervical mucus proteome of humans and rhesus macaques.

Purpose: Endocervical mucus changes play a key role in regulating fertility throughout the menstrual cycle and in response to hormonal contraceptives. Non-human primates (NHP) provide the most translational animal model for reproductive tract studies, as they have hormonally-regulated menstrual cycles and mucus changes, similar to women.

Experimental Design: We used TMT labelling and LC-LC/MS to compare the proteins found in the mucus of the rhesus macaque to the mucus of the human endocervix.

Factors Associated With Perceived Trust of False Abortion Websites: Cross-sectional Online Survey.

Background: Most patients use the internet to search for health information. While there is a vast repository of searchable information online, much of the content is unregulated and therefore potentially incorrect, conflicting, or confusing. Abortion information online is particularly prone to being inaccurate as antichoice websites publish purposefully misleading information in formats that appear as neutral resources.

Willingness to Use Cannabis for Gynecological Conditions: A National Survey.

Expanded legal access to cannabis in the United States has led to its increased use for treating medical conditions. We assessed the use of and attitudes toward cannabis for treating gynecological conditions. We utilized Amazon.