Publications by authors named "Leo Grassion"
Introduction: Biologics provide significant benefits in asthma, reducing exacerbations and symptoms. Some biologics have shown promising results in small subgroups of patients with chronic obstructive pulmonary disease (COPD) and frequent exacerbations. Nevertheless, real-life data on the size of the COPD target population remain scarce.
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- A study found that about 21.9% of patients hospitalized with severe COPD exacerbations were undiagnosed, indicating a consistent issue over the years 2017-2022.
- Factors linked to underdiagnosis included a higher forced expiratory volume (FEV) and being female, suggesting these groups need more attention in diagnosis efforts.
- Importantly, although undiagnosed patients had lower rates of rehospitalization and mortality, those who did have exacerbations faced higher mortality correlated with age and comorbidity, underscoring the importance of proper diagnosis and treatment.
Pulmonary rehabilitation (PR) improves health-related quality-of-life (HRQoL) in individuals with chronic obstructive pulmonary disease (COPD), notably by increasing exercise tolerance. Easy-to-implement sit-to-stand tests can facilitate the assessment of exercise tolerance in routine practice. This retrospective study conducted in a real-life setting was designed to describe the non-paced 3-min sit-to-stand test (3-STST) and to evaluate its relationship with HRQoL (VQ11 questionnaire) to identify the determinants of 3-STST performance and to analyze the evolution of 3-STST performance and HRQoL over the course of a community-based PR program.
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- Noninvasive ventilation (NIV) has been shown to enhance survival and quality of life for ALS patients, but hospital bed shortages have prompted the exploration of at-home NIV initiation with telemonitoring.
- A study analyzed data from 265 ALS patients who received NIV either at home or in-hospital, finding that 70% of those initiated at home adhered to the treatment after 30 days compared to 52% for in-hospital initiation.
- The at-home group also had a faster initiation process, with an average delay of 8.7 days for at-home NIV compared to 29.5 days in hospital, and achieved a 79% rate of nocturnal hypoxaemia correction among adherent patients.
Background: Growing consideration is emerging regarding the burden of persisting sequelae after SARS-CoV-2 infection. Out-patients exhibiting long Covid may benefit from ambulatory rehabilitation which is, to date, poorly documented.
Methods: A longitudinal follow-up over a one-year period was conducted in two ambulatory rehabilitation structures in order to describe the characteristics of real-life patients referred with Covid-19 sequelae and their evolution over the course of rehabilitation.
Article Synopsis
- In patients with COPD, increased neck muscle activity during sleep is a compensatory response to diaphragmatic dysfunction caused by hyperinflation, potentially leading to worse sleep and health outcomes.
- A study using video polysomnography observed that 26 out of 29 COPD patients recovering from severe exacerbations exhibited sleep-related neck-muscle activity, with varying patterns (intermittent or permanent).
- Those with continuous neck-muscle activity experienced poorer sleep quality, had more frequent prior exacerbations, and faced earlier recurrence of severe exacerbations, highlighting the importance of monitoring this activity for better COPD management.
Continuous positive airway pressure (CPAP) is currently the reference treatment for obstructive sleep apnea (OSA). The use of a face mask, although sometimes necessary, is often associated with increased airway obstruction due to mandibular retrusion. We report a small group of patients in whom addition of a cervical collar to a face mask allowed correction of obstructive events.
View Article and Find Full Text PDFRespiratory work is physiologically increased during sleep and leads to severe alterations in COPD patients, especially by raising sleep hypoventilation. The diurnal impact of these nocturnal events may have been underestimated in COPD patients. Impaired sleep and the increase of respiratory work may be one of the major trigger of diurnal events like hypoventilation, exacerbation and even mortality.
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