Publications by authors named "Lenselink A"
Introduction: Over 100 million displaced people rely on health services in humanitarian contexts, defined as unstable or transitory settings created in response to complex emergencies. While services are often described, there is a dearth of evidence on best practices for successful implementation to guide efforts to optimize health delivery. Implementation science is a promising but underutilized tool to address this gap.
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- C57BL/6J and DBA/2J mice exhibit significant behavioral differences linked to hippocampal function, particularly in contextual memory, attributed historically to postsynaptic protein expression variances.
- In DBA mice, there is a notable reduction in the Ras-GAP protein RASAL1 and several presynaptic exocytosis markers, indicating compromised synaptic transmission capabilities.
- Ultrastructural analysis reveals fewer synaptic vesicles and smaller presynaptic clusters in DBA mice, leading to impaired synaptic processing and cognitive function due to altered transmitter release dynamics.
To explain cognitive and memory difficulties observed in some familial hemiplegic migraine (FHM) patients, we examined hippocampal neurotransmission and plasticity in knock-in mice expressing the FHM type 1 (FHM1) R192Q gain-of function mutation in the CACNA1A gene that encodes the α1A subunit of neuronal CaV2.1 channels. We determined stimulus intensity-response curves for anterior commissure-evoked hippocampal CA1 field potentials in strata pyramidale and radiatum and assessed neuroplasticity by inducing long-term potentiation (LTP) and long-term depression (LTD) in anesthetized mice in vivo.
View Article and Find Full Text PDFBackground: Relatives donating peripheral blood stem cells (PBSCs) may be accepted for donation on less strict criteria than unrelated donors. We evaluated the occurrence of adverse events during procedure and follow-up, with a special focus on donors who would have been deferred as unrelated donors.
Study Design And Methods: All 268 related PBSC donors at our center (1996-2006) were included.
Background: Venous thrombosis is one of the leading causes of maternal morbidity and mortality.
Objective: In the MEGA study, we evaluated pregnancy and the postpartum period as risk factors for venous thrombosis in 285 patients and 857 control subjects.
Patients/methods: Between March 1999 and September 2004, consecutive patients with a first episode of venous thrombosis were included from six anticoagulation clinics.