Resistance-Guided Treatment of Gonorrhea: A Prospective Clinical Study.

Background: Novel treatment strategies to slow the continued emergence and spread of antimicrobial resistance in Neisseria gonorrhoeae are urgently needed. A molecular assay that predicts in vitro ciprofloxacin susceptibility is now available but has not been systematically studied in human infections.

Methods: Using a genotypic polymerase chain reaction assay to determine the status of the N.

Extragenital Screening in Men Who Have Sex With Men Diagnoses More Chlamydia and Gonorrhea Cases Than Urine Testing Alone.

Data were evaluated to determine the benefit of extragenital screening among men who have sex with men in detecting chlamydia/gonorrhea infections. More than seventy percent of chlamydia infections and >80% of gonorrhea infections would have been missed with urine testing alone in the course of a year. Extragenital testing is critical for identifying sexually transmitted diseases among men who have sex with men.

Trichomonas vaginalis in selected U.S. sexually transmitted disease clinics: testing, screening, and prevalence.

Background: Trichomonas vaginalis is the most prevalent nonviral sexually transmitted infection in the United States, affecting 3.1% of women of reproductive age. Infection is associated with HIV acquisition and pelvic inflammatory disease.

Adolescent sexually transmitted infections and risk for subsequent HIV.

Objectives: We estimated the risk of HIV associated with sexually transmitted infection (STI) history during adolescence.

Methods: We retrospectively studied a cohort of adolescents (n = 75 273, born in 1985-1993) who participated in the Philadelphia High School STD Screening Program between 2003 and 2010. We matched the cohort to STI and HIV surveillance data sets and death certificates and performed Poisson regression to estimate the association between adolescent STI exposures and subsequent HIV diagnosis.

Trichomonas vaginalis antimicrobial drug resistance in 6 US cities, STD Surveillance Network, 2009-2010.

Nitroimidazoles (metronidazole and tinidazole) are the only recommended drugs for treating Trichomonas vaginalis infection, and previous samples that assessed resistance of such isolates have been limited in geographic scope. We assessed the prevalence of in vitro aerobic metronidazole and tinidazole resistance among T. vaginalis isolates from multiple geographic sites in the United States.

Screening for Chlamydia trachomatis and Neisseria gonorrhoeae among adolescents in Family Court, Philadelphia, Pennsylvania.

Objectives: To evaluate the use of the Family Court System as a venue for screening adolescents, especially males for sexually transmitted diseases (STD).

Goal: To identify, treat, and describe the prevalence of Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (GC) infections among adolescents on probation under the jurisdiction of the Family Court System of Philadelphia from April 2004 through December 2006.

Study Design: We analyzed data from the first several years of this program, which offered education and voluntary noninvasive screening for CT and GC to adolescents adjudicated delinquent and placed on probation through the Family Court of Philadelphia.

School-based screening for Chlamydia trachomatis and Neisseria gonorrhoeae among Philadelphia public high school students.

Context: The prevalence of sexually transmitted diseases among adolescents is high. Innovative screening and treatment programs need evaluation.

Objectives: The objectives of this study were to identify, treat, and describe the prevalence of Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (GC) infections among Philadelphia public high school students.

Learning from clients: an opportunity for sexually transmitted disease programs.

This article summarizes sexually transmitted disease (STD) knowledge, health care-seeking behaviors, and perceived advantages to seeking care from the perspective of 397 STD clinic clients interviewed between 1997 and 1999 in three northeastern cities. More than half reported a prior STD. Mean days delay in seeking treatment was 10.