Publications by authors named "Lennert J Janssen"
Article Synopsis
- The nuclear envelope (NE) breaks down during prometaphase, leading to a mixing of nuclear and cytosolic proteins that must be reestablished for cellular balance.
- Early in mitosis, condensed chromatin prevents the entry of cytosolic proteins, while in late mitosis, the reforming NE excludes large protein structures.
- The study finds that during the reformation of the nucleus, importing smaller proteins is facilitated by specific nuclear localization signals, while a significant amount of proteasomes enter the nucleus, demonstrating the importance of chromatin state and specialized import mechanisms in protein distribution post-mitosis.
